Published online before print November 21, 2002, 10.1148/radiol.2261020141
(Radiology 2003;226:188.)
A more recent version of this article appeared on January 1, 2003
Correlation of Functional MR Imaging Activation Data with Simple Reaction Times1
Kader Karli Oguz, MD,
Nina Mikelashvili Browner, MD,
Vince D. Calhoun, PhD,
Colin Wu, PhD,
Michael A. Kraut, MD and
David M. Yousem, MD
1 From the Russell H. Morgan Department of Radiology and Radiological Sciences, Divisions of Neuroradiology (K.K.O., N.M.B., M.A.K., D.M.Y.) and Psychiatric Neuro-Imaging (V.D.C.), Johns Hopkins Hospital, 600 N Wolfe St, Phipps B-112, Baltimore, MD 21287; and Office of Biostatistics Research, National Heart, Lung, and Blood Institute (C.W.). Received February 22, 2002; revision requested May 15; revision received June 24; accepted July 31. Supported by RPN 99-01-21-03. K.K.O. supported in part by TUBITAK (Scientific and Technical Research Council of Turkey). Address correspondence to D.M.Y. (e-mail: yousem@rad.jhu.edu).
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Figure 1. Transverse activation map in a subject with fast RTs shows activation in the visual (arrowheads; activation in the left cortex greater than that in the right) and sensorimotor cortices (images presented in radiologic convention, where right side of image is left side of brain). The left sensorimotor cortex activation (straight arrows) is greater than that of the right (curved arrow). No supplemental motor cortex activation is seen.
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Figure 2. Transverse activation map in a subject with slow RTs. Less activation is seen in the visual and motor cortices than that in the subject with fast RTs in Figure 1.
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Figure 3a. Transverse activation group maps of subjects with (a) fast and (b) slow RTs. Subjects with fast RTs show more activation in the visual (arrowheads) and sensorimotor (arrows) cortices than do subjects with slow RTs. Even the intensity of the activation is greater in the subjects with fast RTs (red and orange areas show greater statistical correlation than do yellow and green areas).
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Figure 3b. Transverse activation group maps of subjects with (a) fast and (b) slow RTs. Subjects with fast RTs show more activation in the visual (arrowheads) and sensorimotor (arrows) cortices than do subjects with slow RTs. Even the intensity of the activation is greater in the subjects with fast RTs (red and orange areas show greater statistical correlation than do yellow and green areas).
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Figure 4. Transverse subtraction map of activation in the fast RT group versus that in the slow RT group shows the difference in activation volumes in the left visual and sensorimotor cortices. Interestingly, the difference in right sensorimotor cortex activation between the two groups becomes more striking. It is well known that unilateral motor cortex activation often involves both sensorimotor cortices; therefore, the right-sided differences may be discovered by comparing the group maps in Figures 3 and 4.
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Copyright © 2002 by the Radiological Society of North America.
