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Published online before print January 31, 2003, 10.1148/radiol.2263011970

(Radiology 2003;226:880.)

A more recent version of this article appeared on March 1, 2003
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Do Highly Concentrated Gadolinium Chelates Improve MR Brain Perfusion Imaging? Intraindividually Controlled Randomized Crossover Concentration Comparison Study of 0.5 versus 1.0 mol/L Gadobutrol1

Bernd Tombach, MD, Thomas Benner, PhD, Peter Reimer, MD, Gerhard Schuierer, MD, Eva-Maria Fallenberg, MD, Viviane Geens, MD, Thomas Wels, MD and A. Gregory Sorensen, MD

1 From the Dept of Clinical Radiology, Univ of Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany (B.T., E.M.F.); Dept of Radiology/Nuclear Magnetic Resonance Center, Massachusetts General Hosp, Boston (T.B., A.G.S.); Dept of Radiology, Karlsruhe, Academic Teaching Hosp of Freiburg, Germany (P.R.); Dept of Radiology, Institute of Neuroradiology, Bezirksklinikum Regensburg, Germany (G.S.); and Schering, Berlin, Germany (V.G., T.W.). Received Dec 3, 2001; revision requested Jan 18, 2002; revision received May 20; accepted Jul 1. Supported in part by Schering, Berlin, Germany. A.G.S. supported in part by grant PHS RO1NS38477. Address correspondence to B.T. (e-mail: tombach@uni-muenster.de).



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  		Figure 1. A, Sagittal scout MR image obtained in a 29-year-old man (weight, 93 kg) shows paraxial position of the images in B and C. B, C, Transverse single-section dynamic susceptibility-weighted gradient-echo MR images (31.7/22, 225 x 300-mm field of view, 48 x 128 acquisition matrix, 128 x 128 image matrix, 6-mm section thickness) of the middle cerebral artery, putamen, cortex, and white matter in the same man. ROIs marked for the arterial input function (B) and in the putamen (C) are shown. D, E, Signal intensity-time curves for 28 mL of the 1.0 mol/L gadobutrol formulation (D) and 56 mL of the 0.5 mol/L gadobutrol formulation (E) in the putamen of the same man.

 


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  		Figure 2. Graphs illustrate the different grades of arterial bolus quality based on a blinded reader’s experience using a five-grade scale to assess the shape of the curve, steepness of the signal intensity decrease, bolus width (wide or narrow), signal intensity loss, smoothness of the curve (smooth or jagged), and presence of a second-pass enhancement peak. Error bars represent the SD of the arterial input function ROI at each time point. The scaling of the y axis of each graph is different.

 


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  		Figure 3. Mean transit time (left), rrCBF (middle), and rrCBV (right) maps obtained after the administration of the 0.5 mol/L (top) and 1.0 mol/L (bottom) gadobutrol formulations in a 36-year-old man.

 




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