HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by François, C. J. Articles by Finn, J. P. Search for Related Content PubMed PubMed Citation Articles by François, C. J. Articles by Finn, J. P.

Analysis of Cardiopulmonary Transit Times at Contrast Material–enhanced MR Imaging in Patients with Heart Disease¹

¹ From the Department of Radiology (C.J.F., S.M.S., J.P.F.) and Division of Cardiology (R.O.B.), Northwestern University Medical School, Chicago, Ill. Received April 5, 2002; revision requested June 14; final revision received October 11; accepted October 14. Address correspondence to J.P.F., Department of Radiological Sciences, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095-1721 (e-mail: pfinn@mednet.ucla.edu).

View larger version (18K): [in a new window]   Figure 1. Graph shows a weak correlation between 1/(time to peak signal intensity in the carotid artery bifurcation) and EF (P < .001).

View larger version (19K): [in a new window]   Figure 2. Graphs show distribution of transit times in the carotid artery bifurcation. Between control subjects and patients, there is overlap in times; however, the mean transit times are significantly greater in patients than they are in control subjects (P < .001). A, Time to first appearance. B, Time to peak signal intensity.

View larger version (16K): [in a new window]   Figure 3. Normalized distribution curves of times to peak signal intensity in the carotid artery bifurcation in control subjects and in patients with an EF of less than 50% versus EF greater than 50%. A, Patients with CAD. B, Patients with LV hypertrophy (LVH). Patients with an EF of less than 50% have the longest transit times; however, even patients with an EF of greater than 50% and CAD or LV hypertrophy have, on average, a transit time significantly (P < .05) prolonged compared with that of control subjects.

View larger version (16K): [in a new window]   Figure 4. Graphs show time to peak signal intensity in patients with diastolic and systolic dysfunction. A, Transit time in the pulmonary artery. B, Transit time in the carotid artery bifurcation. There was no statistically significant difference in mean peak transit times to the pulmonary artery between patients with diastolic or systolic dysfunction. However, the difference in mean peak transit times to the carotid artery bifurcation was significant.

View larger version (19K): [in a new window]   Figure 5. ROC curves with transit times measured at various regions in the circulation. A, Time to first appearance. B, Peak signal intensity transit time. Dashed line = test of no discriminative ability, AO = ascending aorta, CA = carotid artery bifurcation, FPR = false-positive rate, IJ = internal jugular vein, PA = pulmonary artery, TPR = true-positive rate.