Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Published online before print March 27, 2003, 10.1148/radiol.2273020518
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, J. J.
Right arrow Articles by Thrall, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, J. J.
Right arrow Articles by Thrall, J. H.

Biomarkers in Imaging: Realizing Radiology’s Future1

John J. Smith, MD, JD, A. Gregory Sorensen, MD and James H. Thrall, MD

1 From the Department of Radiology and MGH Center for Biomarkers in Imaging, Massachusetts General Hospital, 15 Parkman St, WACC 515, Boston, MA 02114. Received May 6, 2002; revision requested July 10; revision received August 13; accepted October 1. Address correspondence to J.J.S. (e-mail: smith.john@mgh.harvard.edu).



View larger version (11K):

[in a new window]
 
Typical industrial product-development pathway outlines steps necessary to initially identify a promising site of therapeutic action and potential therapy that affects that site and then validate that therapy for clinical use. In this diagram, targets are typically molecular steps or events in the physiology or pathophysiology that could be targeted with new therapies, such as a receptor or a signal transduction pathway. "Leads" are novel compounds or devices that might act on such targets.

 





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2003 by the Radiological Society of North America.