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Age-related Changes in Conventional, Magnetization Transfer, and Diffusion-Tensor MR Imaging Findings: Study with Whole-Brain Tissue Histogram Analysis¹   

¹ From the Neuroimaging Research Unit (M.R., G.I., M.C., M.P.S., M.F.) and Clinical Trials Unit (G.C.) of the Department of Neuroscience, and Department of Neuroradiology (S.G.), Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy; and Neurometabolic Unit, Institute of Neurological Sciences, University of Siena, Italy (N.D.S.). Received June 18, 2002; revision requested August 9; revision received September 24; accepted October 25. Address correspondence to M.F. (e-mail: filippi.massimo@hsr.it).

View larger version (65K): [in a new window]   Figure 1. Transverse T2-weighted MR image (3,300/98) (A), MTR maps (B and E), ADC maps (C and F), and FA maps (D and G) of the brain obtained at the level of the lateral ventricles in a 45-year-old healthy man. MTR, ADC, and FA maps constructed before (B-D) and after (E-G) coregistration with the T2-weighted image (A) are shown.

View larger version (25K): [in a new window]   Figure 2a. Normalized (a) MTR, (b) ADC, and (c) FA histogram values from the brain parenchyma of a 38-year-old healthy woman that were obtained after removal of cerebrospinal fluid and extracerebral tissue pixels.

View larger version (18K): [in a new window]   Figure 2b. Normalized (a) MTR, (b) ADC, and (c) FA histogram values from the brain parenchyma of a 38-year-old healthy woman that were obtained after removal of cerebrospinal fluid and extracerebral tissue pixels.

View larger version (21K): [in a new window]   Figure 2c. Normalized (a) MTR, (b) ADC, and (c) FA histogram values from the brain parenchyma of a 38-year-old healthy woman that were obtained after removal of cerebrospinal fluid and extracerebral tissue pixels.

View larger version (18K): [in a new window]   Figure 3a. Scatterplots of (a) number of hyperintense lesions at T2-weighted MR imaging and (b) NBV (in milliliters), both correlated with age in the entire subject population. Subject age correlated significantly with both NBV and number of hyperintense lesions.

View larger version (17K): [in a new window]   Figure 3b. Scatterplots of (a) number of hyperintense lesions at T2-weighted MR imaging and (b) NBV (in milliliters), both correlated with age in the entire subject population. Subject age correlated significantly with both NBV and number of hyperintense lesions.

View larger version (42K): [in a new window]   Figure 4. Scatterplots of MTR histogram-derived (in percentages, top row), ADC histogram-derived (in mm2/sec x 10-3, middle row), and FA histogram-derived (bottom row) measurements correlated with age in the entire subject population. Mean ADC, ADC peak height, and FA peak height correlated significantly with subject age.