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Quantitative CT Indexes in Idiopathic Pulmonary Fibrosis: Relationship with Physiologic Impairment¹

¹ From the Departments of Radiology (A.C.B., A.M.L., D.M., D.A.L.) and Preventive Medicine and Biometrics (G.K.G.), University of Colorado Health Sciences Center, 3025 E 11th Ave, Denver, CO 80262; and Biogen, Cambridge, Mass (C.M.B.). From the 2000 RSNA scientific assembly. Received March 21, 2002; revision requested June 4; final revision received December 19; accepted February 24, 2003. Supported by Biogen. Address correspondence to A.C.B. (e-mail: alan.best@uchsc.edu).

View larger version (120K): [in a new window]   Figure 1a. (a) Transverse thin-section CT image in a normal lung. (b) Frequency histogram for a normal lung. Note the degrees of skewness (asymmetry) and kurtosis (peakedness) and mean lung attenuation. COUNT = pixel count.

View larger version (13K): [in a new window]   Figure 1b. (a) Transverse thin-section CT image in a normal lung. (b) Frequency histogram for a normal lung. Note the degrees of skewness (asymmetry) and kurtosis (peakedness) and mean lung attenuation. COUNT = pixel count.

View larger version (122K): [in a new window]   Figure 2a. (a) Transverse thin-section CT image shows the lungs in a patient with IPF. (b) Frequency histogram for a lung in a patient with IPF. Note the reduced skewness and kurtosis and increased mean attenuation compared with those in a normal lung. (c) Segmented thin-section CT image in the lungs of a patient with IPF. Note areas of lung included automatically by the thresholding program (red) and regions excluded manually, such as bronchial branches and large vessels (dark gray).

View larger version (18K): [in a new window]   Figure 2b. (a) Transverse thin-section CT image shows the lungs in a patient with IPF. (b) Frequency histogram for a lung in a patient with IPF. Note the reduced skewness and kurtosis and increased mean attenuation compared with those in a normal lung. (c) Segmented thin-section CT image in the lungs of a patient with IPF. Note areas of lung included automatically by the thresholding program (red) and regions excluded manually, such as bronchial branches and large vessels (dark gray).

View larger version (183K): [in a new window]   Figure 2c. (a) Transverse thin-section CT image shows the lungs in a patient with IPF. (b) Frequency histogram for a lung in a patient with IPF. Note the reduced skewness and kurtosis and increased mean attenuation compared with those in a normal lung. (c) Segmented thin-section CT image in the lungs of a patient with IPF. Note areas of lung included automatically by the thresholding program (red) and regions excluded manually, such as bronchial branches and large vessels (dark gray).