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DOI: 10.1148/radiol.2292021007
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Gadopentetate Dimeglumine versus Ultrasmall Superparamagnetic Iron Oxide for Dynamic Contrast-enhanced MR Imaging of Tumor Angiogenesis in Human Colon Carcinoma in Mice1

Quido G. de Lussanet, MD, Walter H. Backes, PhD, Arjan W. Griffioen, PhD, Jos M. A. van Engelshoven, MD, PhD and Regina G. H. Beets-Tan, MD, PhD

1 From the Department of Radiology (Q.G.d.L., W.H.B., J.M.A.v.E., R.G.H.B.T.) and Angiogenesis Laboratory of Internal Medicine (A.W.G.), Maastricht University Hospital, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, the Netherlands. From the 2002 RSNA scientific assembly. Received August 15, 2002; revision requested September 24; final revision received March 20, 2003; accepted April 7. Supported in part by the Cardiovascular Research Institute Maastricht (CARIM), the Netherlands. Address correspondence to Q.G.d.L. (e-mail: qdlu@rdia.azm.nl).



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  		Figure 1. Color-coded tumor KPS maps and corresponding transverse T2-weighted anatomic images in, A, a mouse with a tumor with high KPS at the rim (arrows) with respect to the tumor core and, B, a mouse with a heterogeneous tumor.

 


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  		Figure 2. Scatterplot of KPS in tumor rim versus MVD in tumor rim shows a smaller range of MVD with gadopentetate dimeglumine ({diamondsuit}) than with USPIO ({square}); regression lines illustrate that correlation between KPS and MVD values for gadopentetate dimeglumine (solid line) and USPIO (dotted line) does not significantly differ (P > .4).

 


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  		Figure 3a. (a) Graph of USPIO plasma signal intensity time course. Signal intensity in the aorta ({triangleup}) shows an immediate decrease after contrast agent injection (t0) followed by a slow recovery (dotted line), while the average signal intensity in tumor ({circ}) shows a small but gradual increase (solid line) after contrast agent injection. (b) Graph of gadopentetate dimeglumine plasma signal intensity time course. Signal intensity in the aorta ({triangleup}) shows an immediate increase after contrast agent injection (t0) followed by a biexponential decline (dotted line), while the average signal intensity in tumor ({circ}) shows a substantial increase but diminishes again (solid line) approximately 15 minutes after contrast agent injection.

 


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  		Figure 3b. (a) Graph of USPIO plasma signal intensity time course. Signal intensity in the aorta ({triangleup}) shows an immediate decrease after contrast agent injection (t0) followed by a slow recovery (dotted line), while the average signal intensity in tumor ({circ}) shows a small but gradual increase (solid line) after contrast agent injection. (b) Graph of gadopentetate dimeglumine plasma signal intensity time course. Signal intensity in the aorta ({triangleup}) shows an immediate increase after contrast agent injection (t0) followed by a biexponential decline (dotted line), while the average signal intensity in tumor ({circ}) shows a substantial increase but diminishes again (solid line) approximately 15 minutes after contrast agent injection.

 


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  		Figure 4. Graph of R2* changes in tumor after contrast agent injection shows that R2* changes are much greater with USPIO ({square}) than with gadopentetate dimeglumine ({diamondsuit}); error bars represent standard errors of the mean.

 




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