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Speech Delay in Children: A Functional MR Imaging Study¹

¹ From the Department of Radiology, Miami Childrens’ Hospital, 3100 SW 62nd Ave, Miami, FL 33155. From the 2002 RSNA scientific assembly. Received December 16, 2002; revision requested February 27, 2003; final revision received July 9; accepted July 16. Address correspondence to N.R.A. (e-mail: nolan.altman@mch.com).

View larger version (20K): [in a new window]   Figure 1. Graph shows regions of activation in patients with normal speech (black bars) and speech delay (gray bars). Notice the predominance of temporal and frontal lobe activation and the difference between left and right temporal lobes between the groups. LO = left occipital, RO = right occipital, LT = left temporal, RT = right temporal, LF = left frontal, RF = right frontal, LP = left parietal, RP = right parietal.

View larger version (97K): [in a new window]   Figure 2. Auditory passive paradigms in a 5-year-old boy with speech delay (left) and a 5-year-old boy with normal speech (right). Colored areas of activation are depicted over transverse T1-weighted MR (300/14) images. Intensity is indicated by colors. Yellow indicates the highest intensity; green, high intensity; blue, low intensity; and purple, lowest intensity. The image of the patient with speech delay demonstrates activation in the right temporal lobe, whereas the image of the subject with normal speech demonstrates activation in the left.

View larger version (20K): [in a new window]   Figure 3. Graph shows number of patients over 3 years of age in the control group and in the speech delay group with left (black bars) or right (gray bars) hemisphere dominance, assigned by lateralization index sign (positive for left hemisphere dominance, and negative for right hemisphere dominance). The differences are statistically significant (P = .036, Fisher exact test).