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Induction of Diabetes in Nonhuman Primates by Means of Temporary Arterial Embolization and Selective Arterial Injection of Streptozotocin¹

¹ From the Department of Diagnostic Imaging, Yale University School of Medicine, PO Box 208042, New Haven, CT 06520-8042 (M.G.T.); and the Transplantation and Autoimmunity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (B.H., D.B., S.S., N.P., D.M.H.); Radiology Department, Warren Grant Magnuson Clinical Center (Z.N., R.C.); and Surgery Service, Veterinary Resources Program, Office of Research Services (J.B.), Department of Health and Human Services, National Institutes of Health, Bethesda, Md. From the 2002 RSNA scientific assembly. Received October 31, 2002; revision requested January 13, 2003; final revision received May 12; accepted May 20. Address correspondence to M.G.T. (e-mail: michael.tal@yale.edu).

View larger version (107K): [in a new window]   Figure 1. Anteroposterior angiogram shows the splenic artery (white arrow), hepatic artery (black arrow), and right (white arrowhead) and left (black arrowhead) renal arteries.

View larger version (101K): [in a new window]   Figure 2. Anteroposterior angiogram obtained with selective contrast material injection into the celiac artery shows the splenic artery (white arrow), proper hepatic artery (black arrow), gastroduodenal artery (black arrowhead), and gastric artery (white arrowhead).

View larger version (133K): [in a new window]   Figure 3. Anteroposterior angiogram obtained with selective contrast material injection via microcatheter shows the proper hepatic artery (arrow).

View larger version (113K): [in a new window]   Figure 4. Postembolization anteroposterior angiogram obtained with selective contrast material injection into the celiac artery prior to streptozotocin infusion shows occluded hepatic (black arrow) and gastric (white arrowhead) arteries and patent splenic (white arrow) and gastroduodenal (black arrowhead) arteries.

View larger version (24K): [in a new window]   Figure 5. Graph shows the three-phase response in blood glucose levels at three different times after selective arterial injection of streptozotocin (STZ): transient hyperglycemia (the first phase), profound hypoglycemia due to beta cell death and uncontrolled secretion of insulin (the second phase), and persistent hyperglycemia requiring insulin treatment (the third phase).

View larger version (173K): [in a new window]   Figure 6a. Photomicrographs of pancreatic islet specimens obtained from a pigtail macaque (a) prior to streptozotocin injection and (b) 180 days after streptozotocin injection. Note the uptake of stain indicating the presence of insulin, glucagon, and somatostatin in a and the near complete absence of insulin staining in b. (Hematoxylin-eosin stain; original magnification, x100.)

View larger version (176K): [in a new window]   Figure 6b. Photomicrographs of pancreatic islet specimens obtained from a pigtail macaque (a) prior to streptozotocin injection and (b) 180 days after streptozotocin injection. Note the uptake of stain indicating the presence of insulin, glucagon, and somatostatin in a and the near complete absence of insulin staining in b. (Hematoxylin-eosin stain; original magnification, x100.)