Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1148/radiol.2303021801
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmed, M.
Right arrow Articles by Goldberg, S. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmed, M.
Right arrow Articles by Goldberg, S. N.

Radiofrequency Ablation: Effect of Surrounding Tissue Composition on Coagulation Necrosis in a Canine Tumor Model1

Muneeb Ahmed, MD, Zhengjun Liu, MD, Karim S. Afzal, BA, Dawn Weeks, RTR, S. Melvyn Lobo, MD, Jonathan B. Kruskal, MD, PhD, Robert E. Lenkinski, PhD and S. Nahum Goldberg, MD

1 From the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215. From the 2002 RSNA scientific assembly. Received December 30, 2002; revision requested March 10, 2003; final revision received July 10; accepted August 18. Supported by National Cancer Institute grant RO1-CA87992–01A1. Address correspondence to S.N.G. (e-mail: sgoldber@caregroup.harvard.edu).



View larger version (62K):

[in a new window]
  		Figure 1. Effect of different tissue sites on RF tumor ablation effectiveness. A, Tumor implanted in kidney. B, Tumor implanted subcutaneously. C, Tumor implanted in lung. Significantly smaller coagulation diameter (mean, 7 mm) was achieved in the kidney tissue site (A) in comparison to that in subcutaneous (B) and lung (C) tissue sites. In A, viable and perfused tumor, as evidenced by the uptake of 2% Evans blue dye (arrows), persists around the central ablation zone. In B, greater coagulation diameter (9 mm [arrows]) is observed in subcutaneous tumors than in kidney tumors, but viable tumor tissue persists in the tumor margins. In C, greatest coagulation diameter (14 mm) was observed in lung tumors. Tumor was completely treated in this case, including a margin of normal surrounding lung parenchyma (black arrows). White arrow indicates tumor-ablation margin interface.

 


View larger version (14K):

[in a new window]
  		Figure 2. Graph plots correlation of overall baseline system impedance to RF-induced coagulation diameter for tumors treated in lung, subcutaneous, and kidney tissue sites. Linear correlation is suggested by increasing RF-induced coagulation with increasing electric impedance of surrounding normal parenchyma (y = 167.4x + 51.4, R2 = 0.65).

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2004 by the Radiological Society of North America.