DOI: 10.1148/radiol.2303030853
Severe Acute Respiratory Syndrome: Temporal Lung Changes at Thin-Section CT in 30 Patients1
Gaik C. Ooi, MD,
Pek L. Khong, MD,
Nestor L. Müller, MD, PhD,
Wai C. Yiu, MD,
Lin J. Zhou, MD,
James C. M. Ho, MD,
Bing Lam, MD,
Savvas Nicolaou, MD and
Kenneth W. T. Tsang, MD
1 From the Departments of Diagnostic Radiology (G.C.O., P.L.K., L.J.Z.) and Medicine (J.C.M.H., B.L., K.W.T.T.), University of Hong Kong, Queen Mary Hospital, Rm 405, Block K, Pokfulam Rd, Hong Kong, Special Administrative Region, China; Department of Radiology, Queen Mary Hospital, Hong Kong, Special Administrative Region, China (W.C.Y.); and Department of Radiology, Vancouver General Hospital, University of British Columbia, Canada (N.L.M., S.N.). Received June 2, 2003; revision requested June 23; final revision received September 8; accepted September 16. Address correspondence to G.C.O. (e-mail: cgcooi@hkucc.hku.hk).
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Figure 1. Line graph shows median thin-section CT scores at various time points in weeks after onset of symptoms. Scores peaked at 2nd week of illness, with a slow decline thereafter and substantial scores after the 4th week.
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Figure 2. Stacked-bar graph shows distribution of different patterns of lung changes on thin-section CT scans at various time points from onset of symptoms. Dark gray = reticular pattern, white = mixed pattern, light gray = consolidation, black = ground-glass opacities, striped = normal.
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Figure 3. Stacked-bar graph shows distribution of different types of ground-glass opacities on thin-section CT scans at various time points from onset of symptoms. Light gray = ground-glass opacities plus irregular linear opacities, dark gray = ground-glass opacities plus intralobular septal thickening, white = ground-glass opacities plus smooth interlobular septal thickening, black = ground-glass opacities.
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Figure 4a. Transverse thin-section CT scans in different patients show (a) ground-glass opacities associated with smooth interlobular and intralobular septal thickening, (b) ground-glass opacities with superimposed irregular linear opacities, and (c) predominantly reticular pattern in lower lobes (arrows).
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Figure 4b. Transverse thin-section CT scans in different patients show (a) ground-glass opacities associated with smooth interlobular and intralobular septal thickening, (b) ground-glass opacities with superimposed irregular linear opacities, and (c) predominantly reticular pattern in lower lobes (arrows).
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Figure 4c. Transverse thin-section CT scans in different patients show (a) ground-glass opacities associated with smooth interlobular and intralobular septal thickening, (b) ground-glass opacities with superimposed irregular linear opacities, and (c) predominantly reticular pattern in lower lobes (arrows).
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Figure 5a. Transverse thin-section CT scans in 45-year-old woman with SARS. (a) Scan obtained on day 10 of illness shows diffuse ground-glass opacities that affected upper lobes. (b) Scan obtained on day 20 of illness shows irregular linear opacities that developed in the areas of ground-glass opacities. (c) Scan obtained on day 31 of illness shows that reticulation superimposed on ground-glass opacities persisted, although reduced in extent.
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Figure 5b. Transverse thin-section CT scans in 45-year-old woman with SARS. (a) Scan obtained on day 10 of illness shows diffuse ground-glass opacities that affected upper lobes. (b) Scan obtained on day 20 of illness shows irregular linear opacities that developed in the areas of ground-glass opacities. (c) Scan obtained on day 31 of illness shows that reticulation superimposed on ground-glass opacities persisted, although reduced in extent.
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Figure 5c. Transverse thin-section CT scans in 45-year-old woman with SARS. (a) Scan obtained on day 10 of illness shows diffuse ground-glass opacities that affected upper lobes. (b) Scan obtained on day 20 of illness shows irregular linear opacities that developed in the areas of ground-glass opacities. (c) Scan obtained on day 31 of illness shows that reticulation superimposed on ground-glass opacities persisted, although reduced in extent.
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Figure 6a. Transverse thin-section CT scans in 52-year-old man with SARS. (a) Scan obtained on day 12 of illness shows pneumomediastinum (arrows) and ground-glass opacities with superimposed irregular linear opacities in both lungs. (b) Follow-up scan obtained on day 37 of illness shows coarse reticular opacities with bronchial dilatation (arrow) and architectural distortion in the same areas.
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Figure 6b. Transverse thin-section CT scans in 52-year-old man with SARS. (a) Scan obtained on day 12 of illness shows pneumomediastinum (arrows) and ground-glass opacities with superimposed irregular linear opacities in both lungs. (b) Follow-up scan obtained on day 37 of illness shows coarse reticular opacities with bronchial dilatation (arrow) and architectural distortion in the same areas.
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Figure 7a. Transverse thin-section CT scans in 32-year-old woman with SARS. (a) Scan obtained on day 8 of illness shows ground-glass opacities predominantly in right upper lobe. (b) Scan obtained on day 30 of illness shows coarse reticular opacities that developed in right upper lobe, with bronchial dilatation (arrows) and architectural distortion.
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Figure 7b. Transverse thin-section CT scans in 32-year-old woman with SARS. (a) Scan obtained on day 8 of illness shows ground-glass opacities predominantly in right upper lobe. (b) Scan obtained on day 30 of illness shows coarse reticular opacities that developed in right upper lobe, with bronchial dilatation (arrows) and architectural distortion.
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Figure 8a. Transverse thin-section CT scans in 46-year-old woman with SARS. (a) Scan obtained 9 days after onset of symptoms shows consolidation in right lower lobe with patchy subpleural ground-glass opacities in right middle lobe. (b) Scan obtained on day 18 of illness shows mixed pattern that developed, with bandlike and angled consolidation (arrowheads) in right lung base and parenchymal bands (arrows) in the left lung base. (c) Scan obtained on day 38 of illness just before discharge shows complete resolution of abnormalities.
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Figure 8b. Transverse thin-section CT scans in 46-year-old woman with SARS. (a) Scan obtained 9 days after onset of symptoms shows consolidation in right lower lobe with patchy subpleural ground-glass opacities in right middle lobe. (b) Scan obtained on day 18 of illness shows mixed pattern that developed, with bandlike and angled consolidation (arrowheads) in right lung base and parenchymal bands (arrows) in the left lung base. (c) Scan obtained on day 38 of illness just before discharge shows complete resolution of abnormalities.
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Figure 8c. Transverse thin-section CT scans in 46-year-old woman with SARS. (a) Scan obtained 9 days after onset of symptoms shows consolidation in right lower lobe with patchy subpleural ground-glass opacities in right middle lobe. (b) Scan obtained on day 18 of illness shows mixed pattern that developed, with bandlike and angled consolidation (arrowheads) in right lung base and parenchymal bands (arrows) in the left lung base. (c) Scan obtained on day 38 of illness just before discharge shows complete resolution of abnormalities.
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Copyright © 2004 by the Radiological Society of North America.
