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Superiority of Pentobarbital versus Chloral Hydrate for Sedation in Infants during Imaging¹

¹ From the Departments of Anesthesia (K.P.M.), Radiology (K.P.M., P.S., V.E.K., L.C., P.J.F., P.E.B.), Biostatistics (D.Z.), and Orthopaedic Surgery (D.Z.), Children’s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115. Received January 17, 2003; revision requested March 3; final revision received June 23; accepted July 31. Address correspondence to K.P.M. (e-mail: keira.mason@tch.harvard.edu).

View larger version (66K): [in a new window]   Figure 1. Medical conditions that contraindicate nurse-administered sedation.

View larger version (22K): [in a new window]   Figure 2. Bar graph shows comparison of oral pentobarbital and oral chloral hydrate with respect to cases of failed sedation, abnormal oxygen (O2) saturation, unplanned admissions, and adverse events. There was a statistically significant difference (*) between the two groups with respect to abnormal oxygen saturation and total adverse events. Percentage of cases of failed sedation was higher with oral chloral hydrate (1.3%) than with oral pentobarbital (0.5%), although this difference was not statistically significant (n.s.).