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Metastatic Renal Cell Carcinoma: CT-guided Immunotherapy as a Technically Feasible and Safe Approach to Delivery of Gene Therapy for Treatment¹

¹ From the Department of Radiological Sciences, UCLA Medical Center, 10833 Le Conte Ave, B2–168 CHS, Los Angeles, CA 90095-1721. Received December 18, 2002; revision requested February 2, 2003; final revision received August 26; accepted September 29. Address correspondence to R.D.S. (e-mail: rsuh@mednet.ucla.edu).

View larger version (119K): [in a new window]   Figure 1a. Transverse thin-section CT scans used to guide intratumoral injection of IL-2 plasmid DNA show injection at various target sites, including (a) the lung, (b) the liver, (c) a lymph node, and (d) an adrenal gland. Injections were performed with patients in the prone position.

View larger version (122K): [in a new window]   Figure 1b. Transverse thin-section CT scans used to guide intratumoral injection of IL-2 plasmid DNA show injection at various target sites, including (a) the lung, (b) the liver, (c) a lymph node, and (d) an adrenal gland. Injections were performed with patients in the prone position.

View larger version (137K): [in a new window]   Figure 1c. Transverse thin-section CT scans used to guide intratumoral injection of IL-2 plasmid DNA show injection at various target sites, including (a) the lung, (b) the liver, (c) a lymph node, and (d) an adrenal gland. Injections were performed with patients in the prone position.

View larger version (148K): [in a new window]   Figure 1d. Transverse thin-section CT scans used to guide intratumoral injection of IL-2 plasmid DNA show injection at various target sites, including (a) the lung, (b) the liver, (c) a lymph node, and (d) an adrenal gland. Injections were performed with patients in the prone position.

View larger version (119K): [in a new window]   Figure 2a. Intratumoral immunotherapeutic injection into a pulmonary nodule performed with transverse thin-section CT guidance and the patient, a 79-year-old woman, in the prone position. (a) CT scan obtained during first injection cycle shows successful needle placement in a nodule in the left lower lobe. (b) CT scan obtained during second injection cycle demonstrates interval regression of the nodule.

View larger version (140K): [in a new window]   Figure 2b. Intratumoral immunotherapeutic injection into a pulmonary nodule performed with transverse thin-section CT guidance and the patient, a 79-year-old woman, in the prone position. (a) CT scan obtained during first injection cycle shows successful needle placement in a nodule in the left lower lobe. (b) CT scan obtained during second injection cycle demonstrates interval regression of the nodule.