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Alzheimer Disease: Operating Characteristics of PET— A Meta-Analysis¹

¹ From the Duke Center for Clinical Health Policy Research, 2200 W Main St, Suite 220, Durham, NC 27705 (M.B.P., D.C.M., D.B.M., G.P.S.); Departments of Medicine (D.C.M., D.B.M.) and Community and Family Medicine (G.P.S.), Duke University Medical Center, Durham, NC; Department of Veterans Affairs, Durham, NC (D.C.M., D.B.M.); and Department of Medicine, Geneva University Hospital, Switzerland (O.T.R.). Received December 2, 2002; revision requested February 21, 2003; final revision received August 27; accepted September 29. Supported by the Agency for Healthcare Research and Quality contract No. 290–97-0014, task order 7. Address correspondence to M.B.P. (e-mail: meenal.p@duke.edu).

View larger version (18K): [in a new window]   Figure a. (a) Summary ROC curve for all studies on the comparison of PET operating characteristics in healthy control subjects and patients with dementia caused by Alzheimer disease. A high degree of heterogeneity in the specificity and sensitivity estimates is shown. The box indicates the 95% CI around summary estimates of sensitivity and specificity. (b) Summary ROC curve for all studies on the comparison of PET operating characteristics in Alzheimer disease and non-Alzheimer disease dementias. These studies had a lower specificity but a similar sensitivity to those in studies on the comparison of healthy control subjects and patients with Alzheimer disease (a).

View larger version (15K): [in a new window]   Figure b. (a) Summary ROC curve for all studies on the comparison of PET operating characteristics in healthy control subjects and patients with dementia caused by Alzheimer disease. A high degree of heterogeneity in the specificity and sensitivity estimates is shown. The box indicates the 95% CI around summary estimates of sensitivity and specificity. (b) Summary ROC curve for all studies on the comparison of PET operating characteristics in Alzheimer disease and non-Alzheimer disease dementias. These studies had a lower specificity but a similar sensitivity to those in studies on the comparison of healthy control subjects and patients with Alzheimer disease (a).