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Interleukin-6 Promoter Genotype and Restenosis after Femoropopliteal Balloon Angioplasty: Initial Observations¹

¹ From the Departments of Medical and Chemical Laboratory Diagnostics (M.E., C.M., O.W.) and Angiology (M.S., E.M., W.M., S.S., G.E., M.R.), University of Vienna Medical School, Waehringer Guertel 18–20, A-1090 Vienna, Austria. Received May 3, 2003; revision requested July 11; final revision received September 11; accepted October 21. M.E. and M.S. supported by grant P15231 from the Fonds zur Förderung der Wissenschaftlichen Forschung. Address correspondence to O.W. (e-mail: oswald.wagner@univie.ac.at).

View larger version (19K): [in a new window]   Graph shows cumulative patency in 258 patients after PTA of the femoropopliteal artery according to IL-6 genotype. Homozygous carriers of the (–174)C allele exhibited an increased rate of restenosis within 6 months after PTA (log-rank test, P = .0066).