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MR Imaging of the Stomach: Potential Use for Mangafodipir Trisodium— A Study in Swine¹

¹ From the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (C.S.Z., N.M.R.); Eagle Vision Pharmaceutical, Exton, Pa (P.R.S., P.P.H.); and Department of Radiology, Wayne State University, Detroit, Mich (J.H.). Received May 29, 2003; revision requested August 12; final revision received November 12; accepted November 24. Supported in part by grant DK 58420–1 from the NIH to Eagle Vision Pharmaceutical. Address correspondence to C.S.Z., Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02215 (e-mail: czuo@mclean.harvard.edu).

View larger version (95K): [in a new window]   Figure 1. Coronal in vivo MR images obtained in swine stomach, A, before and, B, approximately 30 minutes after administration of mangafodipir trisodium with an intravenous bolus injection at a dose of 5 µmol per kilogram of body weight and with a T1-weighted three-dimensional volumetric interpolated breath-hold examination sequence (3.8/1.6, 25° flip angle, 300 x 300-mm field of view, 2-mm section thickness [128-mm postinterpolation slab thickness], 64 partitions, 228 x 256 matrix). In the contrast-enhanced image, note that the enhancing layer (arrow) is limited to the inner surface of the stomach wall.

View larger version (22K): [in a new window]   Figure 2. Graph shows contrast enhancement in the swine stomach wall at various intervals after administration of gadopentetate dimeglumine (Gd) and mangafodipir trisodium (Mn). The key parameter for comparison of these two contrast agents is not the peak level of enhancement but rather the selectivity and duration of enhancement: A 30% enhancement occurred approximately 30 minutes after mangafodipir trisodium injection and remained relatively constant for at least 40 minutes, compared with the early and abrupt decline in contrast enhancement with gadopentetate dimeglumine. S = MR imaging signal intensity at time t before and after contrast material injection, S0 = MR imaging signal intensity before contrast material injection.

View larger version (96K): [in a new window]   Figure 3. Coronal ex vivo MR images of swine stomach obtained, A, without, and, B, with mangafodipir trisodium injection and a T1-weighted three-dimensional gradient-recalled-echo sequence with fat saturation (6.2/2.2, 45° flip angle, 1.2-mm section thickness [no interpolation], 216 x 512 matrix, and 195 x 260-mm field of view). In B, note the thin and well-defined enhancing layer (arrow) that is confined to the inner portion of the gastric wall and follows the contour of the gastric folds. The image in A appears to be in the transverse plane because the specimen was in a smaller container than that in B.