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DOI: 10.1148/radiol.2321030392
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Thin-Section CT Abnormalities and Pulmonary Gas Exchange Impairment in Workers Exposed to Asbestos1

Andrea Sette, MD, PhD, J. Alberto Neder, MD, PhD, Luiz E. Nery, MD, PhD, Jorge Kavakama, MD, Reinaldo T. Rodrigues, MD, Mario Terra-Filho, MD, PhD, Sandra Guimarães, MD, PhD, Ericson Bagatin, MD, PhD and Nestor Müller, MD, PhD

1 From the Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases (A.S., J.A.N., L.E.N., S.G.), and Dept of Radiology (R.T.R.), Federal Univ of São Paulo, Rua Professor Francisco de Castro 54, Vila Clementino, CEP 04020–050, São Paulo, Brazil; Occupational Health Service, State Univ of Campinas, São Paulo, Brazil (E.B.); Div of Respiratory Diseases, Univ of São Paulo, Brazil (J.K., M.T.F.); and Dept of Radiology, Vancouver General Hospital, BC, Canada (N.M.). Received Mar 17, 2003; revision requested May 30; final revision received Oct 8; accepted Nov 20. Supported in part by a research grant from FAPESP-Brazil (No. 96–10415-6). A.S. supported by a fellowship grant from CNPq-Brazil. S.G. supported by a fellowship grant from FAPESP-Brazil. Address correspondence to J.A.N. (e-mail: albneder@pneumo.epm.br).



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  		Figure 1. Plots show individual values of pulmonary gas exchange variables at rest (DLCO) and during exercise ({Delta}P[A-a]O2/VO2) in asbestos-exposed workers grouped according to thin-section CT (HRCT) abnormalities ({bullet}) and chest radiographic abnormalities (according to the ILO classification, {circ}). Note the increased frequency of abnormal test results with progresive parenchymal involvement (groups A to E and groups 0 to II), independent of the imaging method. Dashed lines represent the limit for normality. See text and Table 2 for group definitions.

 


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  		Figure 2. Plots show relationship between selected indexes of resting (DLCO) and exercise-induced ({Delta}P[A-a]O2/VO2) gas exchange impairment in asbestos-exposed workers grouped according to thin-section CT (HRCT) and chest radiographic findings (according to ILO classification). There was a significant association between gas exchange impairment (shaded area) and more extensive CT (groups D and E) and radiographic (group II) involvement. Conversely, the probability of a negative functional outcome decreased with less severe disease (group A and group 0). Dashed lines represent the limit for normality. See text and Table 2 for group definitions.

 




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