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Published online before print September 16, 2004, 10.1148/radiol.2332031649
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Severe Acute Respiratory Syndrome: Correlation between Clinical Outcome and Radiologic Features1

David S. C. Hui, MD, K. T. Wong, MD, Gregory E. Antonio, MD, Nelson Lee, MD, Alan Wu, MD, Vincent Wong, MD, Winnie Lau, MD, Justin C. Wu, MD, L. S. Tam, MD, L. M. Yu, MSc, Gavin M. Joynt, MD, Sydney S. C. Chung, MD, Anil T. Ahuja, MD and Joseph J. Y. Sung, MD

1 From Depts of Diagnostic Radiology and Organ Imaging (K.T.W., G.E.A., A.T.A.), Medicine and Therapeutics (D.S.C.H., N.L., A.W., V.W., W.L., J.C.W., L.S.T., J.J.Y.S.), Anesthesia and Intensive Care (G.M.J.), and Surgery (S.S.C.C.), and Centre for Clinical Trials and Epidemiological Research (L.M.Y.), The Chinese Univ of Hong Kong, Prince of Wales Hosp, 30–32 Ngan Shing St, Shatin, Hong Kong SAR. Received Oct 10, 2003; revision requested Jan 5, 2004; revision received Jan 27; accepted Mar 2. Supported by the Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau, Hong Kong. Address correspondence to K.T.W. (e-mail: wongkatakjeffrey@hotmail.com).



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  		Figure 1. Graph shows progression of lung consolidation over time. Mean percentages of consolidation are plotted against corresponding days after fever onset. Clinically determined and radiographically depicted disease progression generally occurred at the beginning of the 2nd week after fever onset. The first pulse of methylprednisolone was administered a median of 8 days after fever onset.

 


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  		Figure 2. Frontal chest radiograph obtained in 23-year-old man with SARS at presentation shows focal airspace opacity in left lower lung zone (5% involvement of total lung parenchyma). The airspace opacity is mostly retrocardiac in location. This patient was successfully treated and discharged.

 


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  		Figure 3. Frontal chest radiograph obtained in 34-year-old woman with SARS 7 days after presentation shows multifocal bilateral consolidation (24% involvement of total lung parenchyma). This patient required prolonged ICU care during the treatment period.

 


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  		Figure 4. Kaplan-Meier curve shows percentages of patients who did not require supplementary oxygen versus percentages of consolidation. The morbidity associated with SARS is reflected by the curve data, which show that even when there was only 10% lung involvement, 50% of patients in the cohort required supplemental oxygen. CXR = chest radiograph.

 




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