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Published online before print October 21, 2004, 10.1148/radiol.2333031018
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Malignant versus Benign Nodules at CT Screening for Lung Cancer: Comparison of Thin-Section CT Findings1

Feng Li, MD, PhD, Shusuke Sone, MD, Hiroyuki Abe, MD, PhD, Heber MacMahon, MD and Kunio Doi, PhD

1 From the Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637 (F.L., H.A., H.M., K.D.), and J. A. Azumi General Hospital, Ikeda, Nagano, Japan (S.S.). From the 2002 RSNA scientific assembly. Received June 30, 2003; revision requested September 9; final revision received February 27, 2004; accepted April 12. Supported in part by USPHS grant CA62625. Address correspondence to F.L. (e-mail: fli@kurt.bsd.uchicago.edu).



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  		Figure 1. Typical appearance of the three patterns, four shapes, and four margins used to classify lesions in this study.

 


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  		Figure 2. Graphs show distribution of sizes among, A, 29 nodules with pure GGO (17 malignant and 12 benign); B, 56 nodules with mixed GGO (27 malignant and 29 benign); and C, 137 nodules with solid opacity (15 malignant and 122 benign). Gray bars = malignant nodules, white bars = benign nodules. For pure and mixed GGO lesions, the size of benign nodules extensively overlaps that of malignant nodules in the 6-15-mm range.

 


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  		Figure 3. Transverse thin-section CT images. A, Image shows a malignant pure GGO lesion (adenocarcinoma) with a round shape (arrows). B, Image shows a benign pure GGO lesion (resolved within 3 months) with a polygonal-complex shape (arrows) that is confined to a secondary lobule.

 


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  		Figure 4. Transverse thin-section CT images. A, B, Images show a malignant mixed GGO lesion (adenocarcinoma) with irregular margins. The nodule shows both GGO in the periphery (arrows) and a high-attenuation zone (arrowhead) in the center. C, D, Images show a benign mixed GGO lesion (nodular fibrosis) with irregular margins. In C, a small air collection (arrowhead) is seen in the nodule. In D, the nodule (arrows) is seen on another section.

 


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  		Figure 5. Transverse thin-section CT images. A, Image shows a malignant nodule (squamous cell carcinoma) with air components (arrowhead) and an irregular margin and gross spiculation (arrows). B, Image shows a small benign solid nodule (stable for more than 2 years) with a polygonal shape (arrows) and somewhat smooth margin.

 




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