DOI: 10.1148/radiol.2363041262
MR Imaging Findings in Autoimmune Hepatitis: Correlation with Clinical Staging1
Fatmir Bilaj, MD,
W. Brian Hyslop, MD, PhD,
Hedrick Rivero, MD,
Zeynep Firat, RT,
Georgeta Vaidean, MD, MPH,
Roshan Shrestha, MD,
John T. Woosley, MD and
Richard C. Semelka, MD
1 From the Departments of Radiology (F.B., W.B.H., H.R., Z.F., R.C.S.), Medicine (R.S.), and Pathology and Laboratory Medicine (J.T.W.), University of North Carolina, CB 7510, 101 Manning Dr, Chapel Hill, NC 27599-7510; and Cardiovascular Disease Program, School of Public Health, University of North Carolina, Chapel Hill, NC (G.V.). Received July 19, 2005; revision requested September 6; revision received November 9; accepted December 23.
Address correspondence to R.C.S. (e-mail: richsem{at}med.unc.edu).
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Figure 1a. Transverse MR images obtained in a 21-year-old woman with mild fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows mild surface liver irregularity with diffuse, fine (<2 mm in diameter), low-signal-intensity fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrotic tissue bands (arrow) to have mildly high signal intensity. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows enhancement of fibrous tissue and a mildly hyperintense reticular network. Prominent varices (arrow) are noted in the gastrohepatic ligament.
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Figure 1b. Transverse MR images obtained in a 21-year-old woman with mild fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows mild surface liver irregularity with diffuse, fine (<2 mm in diameter), low-signal-intensity fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrotic tissue bands (arrow) to have mildly high signal intensity. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows enhancement of fibrous tissue and a mildly hyperintense reticular network. Prominent varices (arrow) are noted in the gastrohepatic ligament.
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Figure 1c. Transverse MR images obtained in a 21-year-old woman with mild fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows mild surface liver irregularity with diffuse, fine (<2 mm in diameter), low-signal-intensity fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrotic tissue bands (arrow) to have mildly high signal intensity. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows enhancement of fibrous tissue and a mildly hyperintense reticular network. Prominent varices (arrow) are noted in the gastrohepatic ligament.
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Figure 2a. Transverse MR images obtained in a 35-year-old woman with moderate fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows that the liver surface is moderately irregular, with 2–5-mm-thick hypointense fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrous tissue band (arrow) to be mildly hyperintense. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows progressive enhancement of the fibrotic tissue bands and a high-signal-intensity reticular network that primarily involves the liver periphery.
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Figure 2b. Transverse MR images obtained in a 35-year-old woman with moderate fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows that the liver surface is moderately irregular, with 2–5-mm-thick hypointense fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrous tissue band (arrow) to be mildly hyperintense. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows progressive enhancement of the fibrotic tissue bands and a high-signal-intensity reticular network that primarily involves the liver periphery.
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Figure 2c. Transverse MR images obtained in a 35-year-old woman with moderate fibrosis. (a) T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows that the liver surface is moderately irregular, with 2–5-mm-thick hypointense fibrotic tissue bands. (b) T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows the fibrous tissue band (arrow) to be mildly hyperintense. (c) Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows progressive enhancement of the fibrotic tissue bands and a high-signal-intensity reticular network that primarily involves the liver periphery.
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Figure 3. Transverse MR images obtained in a 60-year-old woman with severe fibrosis. A, T1-weighted out-of-phase spoiled GRE image (140/2.2, 80° flip angle) shows severe deformation of the liver surface, with thick fibrotic tissue bands and a region of confluent fibrosis (arrows), both of which appear hypointense. B, T2-weighted fat-suppressed image (1500/90, 180° flip angle) shows confluent fibrosis and thick fibrotic tissue to be mildly hyperintense. C, Gadolinium-enhanced delayed-phase spoiled GRE image obtained with fat suppression (147/4.1, 80° flip angle) shows marked homogeneous enhancement of fibrotic tissue.
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Copyright © 2005 by the Radiological Society of North America.
