HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cosottini, M. Articles by Murri, L. Search for Related Content PubMed PubMed Citation Articles by Cosottini, M. Articles by Murri, L.

Diffusion-Tensor MR Imaging of Corticospinal Tract in Amyotrophic Lateral Sclerosis and Progressive Muscular Atrophy¹

¹ From the Departments of Neuroscience (M.C., G.S., A.D.C., L.M.) and Radiology (G.L., M.C.M., C.B.), University of Pisa, via Roma 67, 56100 Pisa, Italy; and Units of Neuroradiology (M.C.) and Medical Physics (M.G.), S. Chiara Hospital, Pisa, Italy. From the 2004 RSNA Annual Meeting. Received August 31, 2004; revision requested November 5; revision received December 3; accepted January 17, 2005. Address correspondence to M.C. (e-mail: mircocosottini{at}libero.it).

View larger version (101K): [in a new window]   Figure 1a. FA maps acquired at different levels along corticospinal tracts. FA maps were calculated after the acquisition of 25 spin-echo echo-planar imaging diffusion-weighted MR images (6500/79.9; field of view, 24 x 24 cm; section thickness, 5 mm; intersection gap, 1 mm; matrix, 128 x 128; number of signals acquired, two; b = 1000 sec/mm2) along noncollinear directions and a reference image without diffusion weighting. For each patient and control subject, two ROIs were placed in (a) both internal capsules, and one ROI was placed on both sides of the (b) cerebral peduncles, (c) pons, and (d) pyramids. Single mean FA, MD, 1, 2, and 3 values were estimated from the averaged values of the diffusion-tensor imaging parameters in the 10 ROIs.

View larger version (106K): [in a new window]   Figure 1b. FA maps acquired at different levels along corticospinal tracts. FA maps were calculated after the acquisition of 25 spin-echo echo-planar imaging diffusion-weighted MR images (6500/79.9; field of view, 24 x 24 cm; section thickness, 5 mm; intersection gap, 1 mm; matrix, 128 x 128; number of signals acquired, two; b = 1000 sec/mm2) along noncollinear directions and a reference image without diffusion weighting. For each patient and control subject, two ROIs were placed in (a) both internal capsules, and one ROI was placed on both sides of the (b) cerebral peduncles, (c) pons, and (d) pyramids. Single mean FA, MD, 1, 2, and 3 values were estimated from the averaged values of the diffusion-tensor imaging parameters in the 10 ROIs.

View larger version (97K): [in a new window]   Figure 1c. FA maps acquired at different levels along corticospinal tracts. FA maps were calculated after the acquisition of 25 spin-echo echo-planar imaging diffusion-weighted MR images (6500/79.9; field of view, 24 x 24 cm; section thickness, 5 mm; intersection gap, 1 mm; matrix, 128 x 128; number of signals acquired, two; b = 1000 sec/mm2) along noncollinear directions and a reference image without diffusion weighting. For each patient and control subject, two ROIs were placed in (a) both internal capsules, and one ROI was placed on both sides of the (b) cerebral peduncles, (c) pons, and (d) pyramids. Single mean FA, MD, 1, 2, and 3 values were estimated from the averaged values of the diffusion-tensor imaging parameters in the 10 ROIs.

View larger version (101K): [in a new window]   Figure 1d. FA maps acquired at different levels along corticospinal tracts. FA maps were calculated after the acquisition of 25 spin-echo echo-planar imaging diffusion-weighted MR images (6500/79.9; field of view, 24 x 24 cm; section thickness, 5 mm; intersection gap, 1 mm; matrix, 128 x 128; number of signals acquired, two; b = 1000 sec/mm2) along noncollinear directions and a reference image without diffusion weighting. For each patient and control subject, two ROIs were placed in (a) both internal capsules, and one ROI was placed on both sides of the (b) cerebral peduncles, (c) pons, and (d) pyramids. Single mean FA, MD, 1, 2, and 3 values were estimated from the averaged values of the diffusion-tensor imaging parameters in the 10 ROIs.

View larger version (10K): [in a new window]   Figure 2a. Graphs show (a) MD (x 10–6 mm2/sec) and (b) FA (dimensionless) at different levels of the corticospinal tract in control subjects. The data points indicate mean values, and the error bars indicate standard deviations.

View larger version (10K): [in a new window]   Figure 2b. Graphs show (a) MD (x 10–6 mm2/sec) and (b) FA (dimensionless) at different levels of the corticospinal tract in control subjects. The data points indicate mean values, and the error bars indicate standard deviations.