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Bolus versus Continuous Infusion of Microbubble Contrast Agent for Liver US: Initial Experience¹

¹ From the Department of Radiology and Nuclear Medicine, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany. Received September 19, 2004; revision requested November 24; revision received January 31, 2005; accepted February 28. Address correspondence to M.O., Department of Radiology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan (e-mail: mokada{at}rad.med.kindai.ac.jp).

View larger version (148K): [in a new window]   Figure 1a. Transverse B-mode pulse inversion US scans of liver metastasis in right lobe of liver in 56-year-old woman. ROIs were drawn both within the lesion (R1) and in normal hepatic parenchyma (R0) for measurement of liver signal intensity in parenchyma and the lesion. (a) Unenhanced scan with ROIs drawn in normal hepatic parenchyma (intensity, 5.6 dB) and the lesion (intensity, 4.8 dB). Liver-to-lesion contrast is 0.8 dB. (b) Contrast-enhanced scan obtained 7 minutes after start of infusion, with ROIs drawn in normal hepatic parenchyma (intensity, 20.5 dB) and the lesion (intensity, 8.0 dB). Liver-to-lesion contrast is 12.5 dB.

View larger version (143K): [in a new window]   Figure 1b. Transverse B-mode pulse inversion US scans of liver metastasis in right lobe of liver in 56-year-old woman. ROIs were drawn both within the lesion (R1) and in normal hepatic parenchyma (R0) for measurement of liver signal intensity in parenchyma and the lesion. (a) Unenhanced scan with ROIs drawn in normal hepatic parenchyma (intensity, 5.6 dB) and the lesion (intensity, 4.8 dB). Liver-to-lesion contrast is 0.8 dB. (b) Contrast-enhanced scan obtained 7 minutes after start of infusion, with ROIs drawn in normal hepatic parenchyma (intensity, 20.5 dB) and the lesion (intensity, 8.0 dB). Liver-to-lesion contrast is 12.5 dB.

View larger version (21K): [in a new window]   Figure 2a. Graph shows (a) enhancement of normal hepatic parenchyma and (b) liver-to-lesion contrast plotted over time for bolus injection and continuous infusion in a 52-year-old woman with metastasis from colon carcinoma. Arrows indicate time at which MI was increased from 0.7 to 1.3.

View larger version (22K): [in a new window]   Figure 2b. Graph shows (a) enhancement of normal hepatic parenchyma and (b) liver-to-lesion contrast plotted over time for bolus injection and continuous infusion in a 52-year-old woman with metastasis from colon carcinoma. Arrows indicate time at which MI was increased from 0.7 to 1.3.