Published online before print October 26, 2005, 10.1148/radiol.2373041573
Prostate Cancer: Three-dimensional Sonoelastography for in Vitro Detection1
Lawrence S. Taylor, PhD,
Deborah J. Rubens, MD,
Brian C. Porter, PhD,
Zhe Wu, PhD,
Raymond B. Baggs, DVM, PhD,
P. Anthony di Sant'Agnese, MD,
Gyongyi Nadasdy, MD,
David Pasternack, BS,
Edward M. Messing, MD,
Priya Nigwekar, MD and
Kevin J. Parker, PhD
1 From the Departments of Biomedical Engineering (L.S.T.) and Electrical and Computer Engineering (B.C.P., Z.W., K.J.P.), University of Rochester, 240 Hutchison Rd, Rm 205, Rochester, NY 14627-0126; Departments of Radiology (D.J.R.), Laboratory Animal Medicine (R.B.B.), Pathology and Laboratory Medicine (P.A.d.S., P.N.), Environmental Medicine, Strong Memorial Hospital (D.P.), and Urology (E.M.M.), University of Rochester School of Medicine and Dentistry, Rochester, NY; and Department of Pathology, Ohio State Medical Center, Columbus, Ohio (G.N.). Received September 10, 2004; revision requested November 14; revision received December 20; accepted January 21, 2005. Supported in part by NIH grant no. 5 R01 AG016317-03.
Address correspondence to K.J.P. (e-mail: rcbu{at}ece.rochester.edu).
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Figure 1a. Two-dimensional transverse images of a confirmed case of cancer in the midgland. The rectal surface is posterior. (a) Histologic image shows the cancer (arrows), which was outlined in green by the pathologist. (Hematoxylin-eosin stain.) (b) Gray-scale US scan obtained in the same plane as a. The cancer is not visible. (c) Sonoelastographic image corresponding to b. There is a deficit in vibration (arrows), which is indicative of an area of stiffer tissue.
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Figure 1b. Two-dimensional transverse images of a confirmed case of cancer in the midgland. The rectal surface is posterior. (a) Histologic image shows the cancer (arrows), which was outlined in green by the pathologist. (Hematoxylin-eosin stain.) (b) Gray-scale US scan obtained in the same plane as a. The cancer is not visible. (c) Sonoelastographic image corresponding to b. There is a deficit in vibration (arrows), which is indicative of an area of stiffer tissue.
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Figure 1c. Two-dimensional transverse images of a confirmed case of cancer in the midgland. The rectal surface is posterior. (a) Histologic image shows the cancer (arrows), which was outlined in green by the pathologist. (Hematoxylin-eosin stain.) (b) Gray-scale US scan obtained in the same plane as a. The cancer is not visible. (c) Sonoelastographic image corresponding to b. There is a deficit in vibration (arrows), which is indicative of an area of stiffer tissue.
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Figure 2a. In vivo two-dimensional sonoelastographic image coregistered with a histologic slide. Images are all transverse; the rectal surface is posterior. (a) Histologic slide shows cancer anterior and on the patient's left, outlined in green. (b) Gray-scale B-mode US scan is normal. (c) Sonoelastographic image corresponding to b has a dark vibration deficit (arrows) anteriorly and on the left, which corresponds to the pathologically evident cancer in a. Note that the B-mode US scan does not show cancer in that region.
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Figure 2b. In vivo two-dimensional sonoelastographic image coregistered with a histologic slide. Images are all transverse; the rectal surface is posterior. (a) Histologic slide shows cancer anterior and on the patient's left, outlined in green. (b) Gray-scale B-mode US scan is normal. (c) Sonoelastographic image corresponding to b has a dark vibration deficit (arrows) anteriorly and on the left, which corresponds to the pathologically evident cancer in a. Note that the B-mode US scan does not show cancer in that region.
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Figure 2c. In vivo two-dimensional sonoelastographic image coregistered with a histologic slide. Images are all transverse; the rectal surface is posterior. (a) Histologic slide shows cancer anterior and on the patient's left, outlined in green. (b) Gray-scale B-mode US scan is normal. (c) Sonoelastographic image corresponding to b has a dark vibration deficit (arrows) anteriorly and on the left, which corresponds to the pathologically evident cancer in a. Note that the B-mode US scan does not show cancer in that region.
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Figure 3. Three-dimensional reconstruction of prostate cancer within the gland surface. The prostate surface (transparent blue) was reconstructed from B-mode US data; tumor data from sonoelastography (sono) and histologic evaluation are indicated by arrows.
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Figure 4. Four adjacent transverse cross sections (with a 1-mm gap between sections) from a 3D fusion volume show the overlapping sonoelastographic and histologic tumor regions. The prostate surface as reconstructed with B-mode US data is white; histologic data are in yellow. The red region is the histologically derived tumor, and the green region is the sonoelastographically derived tumor. The overlapping regions within the prostate are in yellow. The rectal surface is posterior.
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Copyright © 2005 by the Radiological Society of North America.
