Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online before print December 21, 2005, 10.1148/radiol.2381041720

(Radiology 2005;238:650.)

A more recent version of this article appeared on December 1, 2005
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hatakenaka, M.
Right arrow Articles by Honda, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hatakenaka, M.
Right arrow Articles by Honda, H.

Steroid Myopathy: Evaluation of Fiber Atrophy with T2 Relaxation Time—Rabbit and Human Study1

Masamitsu Hatakenaka, MD, PhD, Hiroyasu Soeda, MD, Takashi Okafuji, MD, Hidetake Yabuuchi, MD, PhD, Satoshi Shiokawa, MD, PhD, Junji Nishimura, MD, PhD and Hiroshi Honda, MD, PhD

1 From the Department of Clinical Radiology, Graduate School of Medical Sciences (M.H., H.S., T.O., H.Y., H.H.), and Department of Immunology and Neuroscience, Medical Institute of Bioregulation (S.S., J.N.), Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City 812-8582, Japan. From the 2004 RSNA Annual Meeting. Received October 6, 2004; revision requested December 15; revision received January 21, 2005; accepted February 21. Supported in part by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Sciences (no. 15500365). Address correspondence to M.H. (e-mail: mhatake{at}radiol.med.kyushu-u.ac.jp).



View larger version (70K):

[in a new window]
  		Figure 1a: Representative transverse spin-echo MR images (repetition time msec/echo time msec, 2000/25) obtained in a rabbit (a) before and (b) after steroid treatment. The ROIs (1 and 2) are designated to enable calculation of the T2 relaxation time of the soleus and gastrocnemius muscles, respectively.

 


View larger version (63K):

[in a new window]
  		Figure 1b: Representative transverse spin-echo MR images (repetition time msec/echo time msec, 2000/25) obtained in a rabbit (a) before and (b) after steroid treatment. The ROIs (1 and 2) are designated to enable calculation of the T2 relaxation time of the soleus and gastrocnemius muscles, respectively.

 


View larger version (65K):

[in a new window]
  		Figure 2a: Representative photomicrographs of histologic specimens of the gastrocnemius muscle obtained in (a) control rabbits and (b) rabbits treated with steroids. The extracellular space is greater in rabbits treated with steroids than in control rabbits. (Hematoxylin-eosin stain; original magnification, x100.)

 


View larger version (94K):

[in a new window]
  		Figure 2b: Representative photomicrographs of histologic specimens of the gastrocnemius muscle obtained in (a) control rabbits and (b) rabbits treated with steroids. The extracellular space is greater in rabbits treated with steroids than in control rabbits. (Hematoxylin-eosin stain; original magnification, x100.)

 


View larger version (11K):

[in a new window]
  		Figure 3: Scatterplot of T2 relaxation time versus ECSR in the gastrocnemius muscle. T2 relaxation time correlates well with ECSR. The r and P values are 0.813 and .0013, respectively. {circ} = control rabbits, {bullet} = rabbits treated with steroids.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2005 by the Radiological Society of North America.