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DOI: 10.1148/radiol.2402051248
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Neointima Inhibition: Comparison of Effectiveness of Non–Stent-based Local Drug Delivery and a Drug-eluting Stent in Porcine Coronary Arteries1

Ulrich Speck, PhD, Bruno Scheller, MD, Claudia Abramjuk, DVM, Christoph Breitwieser, MD, Juergen Dobberstein, PhD, Michael Boehm, MD and Bernd Hamm, MD

1 From the Department of Radiology, Charité Humboldt-University Berlin, Schumannstr 20-21, D 10117 Berlin, Germany (U.S., C.A., C.B., B.H.); Department of Internal Medicine III, University Hospital, Homburg/Saar, Germany (B.S., M.B.); and Biometry and Applied Statistics, Berlin, Germany (J.D.). From the 2004 RSNA Annual Meeting. Received July 26, 2005; revision requested September 30; revision received October 13; final version accepted November 14. Supported by a grant from the Ministry of Economics and Technology. Address correspondence to U.S. (e-mail: ulrich.speck{at}charite.de).


Figure 1
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  		Figure 1a: Left anterior oblique angiograms 4 weeks after stent placement compare SESs and stents on DEBs: (a) LAD artery DEB (left) and CX artery SES (right), (b) LAD SES (left) and CX DEB (right), (c) LAD DEB (left) and CX SES (right), (d) LAD DEB (left) and CX SES (right), and (e) LAD SES (left) and CX DEB (right). Arrows indicate the artery segments treated with stents. The remaining lumina in the stent segments treated by means of the coated DEBs are larger than or equal to the lumina in the segments treated by means of SESs.

 

Figure 1
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  		Figure 1b: Left anterior oblique angiograms 4 weeks after stent placement compare SESs and stents on DEBs: (a) LAD artery DEB (left) and CX artery SES (right), (b) LAD SES (left) and CX DEB (right), (c) LAD DEB (left) and CX SES (right), (d) LAD DEB (left) and CX SES (right), and (e) LAD SES (left) and CX DEB (right). Arrows indicate the artery segments treated with stents. The remaining lumina in the stent segments treated by means of the coated DEBs are larger than or equal to the lumina in the segments treated by means of SESs.

 

Figure 1
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  		Figure 1c: Left anterior oblique angiograms 4 weeks after stent placement compare SESs and stents on DEBs: (a) LAD artery DEB (left) and CX artery SES (right), (b) LAD SES (left) and CX DEB (right), (c) LAD DEB (left) and CX SES (right), (d) LAD DEB (left) and CX SES (right), and (e) LAD SES (left) and CX DEB (right). Arrows indicate the artery segments treated with stents. The remaining lumina in the stent segments treated by means of the coated DEBs are larger than or equal to the lumina in the segments treated by means of SESs.

 

Figure 1
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  		Figure 1d: Left anterior oblique angiograms 4 weeks after stent placement compare SESs and stents on DEBs: (a) LAD artery DEB (left) and CX artery SES (right), (b) LAD SES (left) and CX DEB (right), (c) LAD DEB (left) and CX SES (right), (d) LAD DEB (left) and CX SES (right), and (e) LAD SES (left) and CX DEB (right). Arrows indicate the artery segments treated with stents. The remaining lumina in the stent segments treated by means of the coated DEBs are larger than or equal to the lumina in the segments treated by means of SESs.

 

Figure 1
View larger version (129K):

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  		Figure 1e: Left anterior oblique angiograms 4 weeks after stent placement compare SESs and stents on DEBs: (a) LAD artery DEB (left) and CX artery SES (right), (b) LAD SES (left) and CX DEB (right), (c) LAD DEB (left) and CX SES (right), (d) LAD DEB (left) and CX SES (right), and (e) LAD SES (left) and CX DEB (right). Arrows indicate the artery segments treated with stents. The remaining lumina in the stent segments treated by means of the coated DEBs are larger than or equal to the lumina in the segments treated by means of SESs.

 

Figure 2
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  		Figure 2: Graph of percentage area stenosis (mean ± standard error of the mean) determined at histomorphometry 4 weeks after intervention in the control group (no drug), paclitaxel in contrast medium group (CM Pac), DEB group, and SES group. The difference to the other groups in percentage area stenosis with the DEB was statistically significant (P < .001 vs the control and paclitaxel-containing contrast medium, P = .003 vs SES).

 

Figure 3
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  		Figure 3: Examples of transverse histologic slices through arteries treated with stents. (Hematoxylin-eosin stain.) CM Pac = paclitaxel in contrast medium. Only a thin layer of neointimal tissue between the vessel lumen and the black stent struts is found in the vessel treated with the DEB, whereas neointimal proliferation resulted in substantial lumen narrowing in the control vessel.

 




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