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DOI: 10.1148/radiol.2412051247
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Painful Metastases Involving Bone: Percutaneous Image-guided Cryoablation—Prospective Trial Interim Analysis1

Matthew R. Callstrom, MD, PhD, Thomas D. Atwell, MD, J. William Charboneau, MD, Michael A. Farrell, MD, Matthew P. Goetz, MD, Joseph Rubin, MD, Jeff A. Sloan, PhD, Paul J. Novotny, MS, Timothy J. Welch, MD, Timothy P. Maus, MD, Gilbert Y. Wong, MD and Kathy J. Brown, BS

1 From the Departments of Diagnostic Radiology (M.R.C., T.D.A., J.W.C., M.A.F., T.J.W., T.P.M., K.J.B.), Oncology (M.P.G., J.R.), Biostatistics (J.A.S., P.J.N.), and Anesthesiology (G.Y.W.), Mayo Clinic, 200 First St SW, Rochester, MN 55905. Received July 25, 2005; revision requested September 29; revision received October 28; accepted November 17; final version accepted February 1, 2006. Supported in part by a grant from Endocare, Irvine, Calif. Address correspondence to M.R.C. (e-mail: callstrom.matthew{at}mayo.edu).


Figure 1
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  		Figure 1: Graphs show worst pain during 24 hours for 14 patients treated with cryoablation, as measured with BPI. Top: Mean responses for all patients (error bars = 95% CIs, N = number of patients who completed BPI questionnaire). Bottom: Individual responses for each patient. Week 0 is response prior to treatment.

 

Figure 2
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  		Figure 2: Graphs show average pain for patients treated with cryoablation, as measured with BPI. Top: Mean responses for all patients (error bars = 95% CIs, N = number of patients who completed BPI questionnaire). Bottom: Individual responses for each patient. Week 0 is response prior to treatment.

 

Figure 3
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  		Figure 3: Graphs show pain interference for patients treated with cryoablation, as measured with BPI. Top: Mean responses for all patients (error bars = 95% CIs, N = number of patients who completed BPI questionnaire). Bottom: Individual responses for each patient. Week 0 is response prior to treatment.

 

Figure 4
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  		Figure 4: Graphs show relief from pain treatments or medications for patients treated with cryoablation, as measured with BPI. Top: Mean responses for all patients (error bars = 95% CIs, N = number of patients who completed BPI questionnaire). Bottom: Individual responses for each patient. Week 0 is response prior to treatment.

 




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