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Published online before print November 20, 2006, 10.1148/radiol.2421051355
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Assessment of Bone Marrow Angiogenesis in Patients with Acute Myeloid Leukemia by Using Contrast-enhanced MR Imaging with Clinically Approved Iron Oxides: Initial Experience1

Lars Matuszewski, MD, Thorsten Persigehl, MD, Alexander Wall, MD, Norbert Meier, PhD, Ralf Bieker, MD, Hendrik Kooijman, PhD, Bernd Tombach, MD, Rolf Mesters, MD, Wolfgang E. Berdel, MD, Walter Heindel, MD and Christoph Bremer, MD

1 From the Departments of Clinical Radiology (L.M., T.P., A.W., N.M., B.T., W.H., C.B.) and Medicine/Hematology and Oncology (R.B., R.M., W.E.B.) and Interdisciplinary Center for Clinical Research (C.B.), University of Muenster, Albert-Schweitzer-Str 33, D-48129 Münster, Germany; and Philips Medical Systems, Hamburg, Germany (H.K.). From the 2003 RSNA Annual Meeting. Received August 13, 2005; revision requested October 20; revision received December 1; accepted January 2, 2006; final version accepted April 10. Address correspondence to C.B. (e-mail: bremerc{at}uni-muenster.de).


Figure 1
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  		Figure 1: A, B, Transverse T2-weighted MR images (4000/100, 90° flip angle; echo train length of 15), and, C, D, corresponding parametric {Delta}R2* maps obtained in 32-year-old healthy man (A and C) and 37-year-old woman with AML (B and D). Note the homogeneous distribution of moderate {Delta}R2* values in C as opposed to the prominent areas of hypervascularized BM in the pelvis in D.

 

Figure 2
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  		Figure 2a: Bar graphs show (a) {Delta}R2* and (b) VVF data in different anatomic regions in healthy volunteers (white bars) and patients with AML (black bars). (a) Significantly higher {Delta}R2* values were seen in all anatomic regions in the AML group compared with values in the control group (P < .05 [*]). (b) Similarly, BM VVF values in the pelvis and the sacrum were significantly increased in the AML group compared with values in the control group (P < .05 [*]). Data are means ± standard errors of the mean calculated at Wilcoxon rank sum testing.

 

Figure 2
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  		Figure 2b: Bar graphs show (a) {Delta}R2* and (b) VVF data in different anatomic regions in healthy volunteers (white bars) and patients with AML (black bars). (a) Significantly higher {Delta}R2* values were seen in all anatomic regions in the AML group compared with values in the control group (P < .05 [*]). (b) Similarly, BM VVF values in the pelvis and the sacrum were significantly increased in the AML group compared with values in the control group (P < .05 [*]). Data are means ± standard errors of the mean calculated at Wilcoxon rank sum testing.

 

Figure 3
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  		Figure 3a: BM sections from (a) control subject and (b) patient with AML immunohistochemically stained with antihuman thrombomodulin antibodies (magnification, x400). In b, note the increased MVD, as represented by the BM hypercellularity in association with multiple collapsed endothelial cell sprouts (arrowheads). There are fewer vessels in a, however, and the vessels are well differentiated.

 

Figure 3
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  		Figure 3b: BM sections from (a) control subject and (b) patient with AML immunohistochemically stained with antihuman thrombomodulin antibodies (magnification, x400). In b, note the increased MVD, as represented by the BM hypercellularity in association with multiple collapsed endothelial cell sprouts (arrowheads). There are fewer vessels in a, however, and the vessels are well differentiated.

 




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