HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sadowski, E. A. Articles by Djamali, A. Search for Related Content PubMed PubMed Citation Articles by Sadowski, E. A. Articles by Djamali, A.

Nephrogenic Systemic Fibrosis: Risk Factors and Incidence Estimation¹

¹ From the Departments of Radiology (E.A.S., R.W.G.), Dermatology (L.K.B., A.L.G.), Medicine (M.R.C., A.D.), and Biophysics (A.L.W.), University of Wisconsin, 600 Highland Ave, Madison, WI 53792-3252. Received December 15, 2006; revision requested January 3, 2007; revision received January 10; final version accepted January 11. Address correspondence to E.A.S. (e-mail: esadowski{at}uwhealth.org).

View larger version (105K): [in this window] [in a new window] [Download PPT slide]   Figure 1a: (a, b) Patient with NSF presented with area of edema, induration, and erythema on (a) the forearm and (b) an erythematous appearance to the skin over the thigh, which spared the groin. (c, d) Histopathologic photomicrographs show markedly increase cellularity with spindle-shaped fibrocytes and mucin with thickened collagen bundles that infiltrate deeply, extending into and widening the septa of the subcutaneous fat. (Hematoxylin-eosin stain; original magnification for c, x10; for d, x60.)

View larger version (98K): [in this window] [in a new window] [Download PPT slide]   Figure 1b: (a, b) Patient with NSF presented with area of edema, induration, and erythema on (a) the forearm and (b) an erythematous appearance to the skin over the thigh, which spared the groin. (c, d) Histopathologic photomicrographs show markedly increase cellularity with spindle-shaped fibrocytes and mucin with thickened collagen bundles that infiltrate deeply, extending into and widening the septa of the subcutaneous fat. (Hematoxylin-eosin stain; original magnification for c, x10; for d, x60.)

View larger version (141K): [in this window] [in a new window] [Download PPT slide]   Figure 1c: (a, b) Patient with NSF presented with area of edema, induration, and erythema on (a) the forearm and (b) an erythematous appearance to the skin over the thigh, which spared the groin. (c, d) Histopathologic photomicrographs show markedly increase cellularity with spindle-shaped fibrocytes and mucin with thickened collagen bundles that infiltrate deeply, extending into and widening the septa of the subcutaneous fat. (Hematoxylin-eosin stain; original magnification for c, x10; for d, x60.)

View larger version (147K): [in this window] [in a new window] [Download PPT slide]   Figure 1d: (a, b) Patient with NSF presented with area of edema, induration, and erythema on (a) the forearm and (b) an erythematous appearance to the skin over the thigh, which spared the groin. (c, d) Histopathologic photomicrographs show markedly increase cellularity with spindle-shaped fibrocytes and mucin with thickened collagen bundles that infiltrate deeply, extending into and widening the septa of the subcutaneous fat. (Hematoxylin-eosin stain; original magnification for c, x10; for d, x60.)

View larger version (10K): [in this window] [in a new window] [Download PPT slide]   Figure 2: Chart shows 1-year incidence of NSF in patients undergoing contrast-enhanced MR (CE-MR) imaging.

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 3a: Bar graphs show relevant clinical and laboratory data in 13 patients with NSF (gray bars) and 125 control patients (white bars) without NSF but with renal insufficiency and ongoing proinflammatory condition at time of contrast-enhanced MR (CE-MR) examination. NSF group was (a) younger and (b) had significantly decreased eGFR, (c) greater sCr levels, (d), greater number of proinflammatory events, and (e) greater number of contrast-enhanced examinations per patient than did control group.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3b: Bar graphs show relevant clinical and laboratory data in 13 patients with NSF (gray bars) and 125 control patients (white bars) without NSF but with renal insufficiency and ongoing proinflammatory condition at time of contrast-enhanced MR (CE-MR) examination. NSF group was (a) younger and (b) had significantly decreased eGFR, (c) greater sCr levels, (d), greater number of proinflammatory events, and (e) greater number of contrast-enhanced examinations per patient than did control group.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3c: Bar graphs show relevant clinical and laboratory data in 13 patients with NSF (gray bars) and 125 control patients (white bars) without NSF but with renal insufficiency and ongoing proinflammatory condition at time of contrast-enhanced MR (CE-MR) examination. NSF group was (a) younger and (b) had significantly decreased eGFR, (c) greater sCr levels, (d), greater number of proinflammatory events, and (e) greater number of contrast-enhanced examinations per patient than did control group.

View larger version (15K): [in this window] [in a new window] [Download PPT slide]   Figure 3d: Bar graphs show relevant clinical and laboratory data in 13 patients with NSF (gray bars) and 125 control patients (white bars) without NSF but with renal insufficiency and ongoing proinflammatory condition at time of contrast-enhanced MR (CE-MR) examination. NSF group was (a) younger and (b) had significantly decreased eGFR, (c) greater sCr levels, (d), greater number of proinflammatory events, and (e) greater number of contrast-enhanced examinations per patient than did control group.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3e: Bar graphs show relevant clinical and laboratory data in 13 patients with NSF (gray bars) and 125 control patients (white bars) without NSF but with renal insufficiency and ongoing proinflammatory condition at time of contrast-enhanced MR (CE-MR) examination. NSF group was (a) younger and (b) had significantly decreased eGFR, (c) greater sCr levels, (d), greater number of proinflammatory events, and (e) greater number of contrast-enhanced examinations per patient than did control group.