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DOI: 10.1148/radiol.2431060194
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Pulmonary Emphysema: Radiation Dose and Section Thickness at Multidetector CT Quantification—Comparison with Macroscopic and Microscopic Morphometry1

Afarine Madani, MD, Viviane De Maertelaer, PhD, Jacqueline Zanen, PhD and Pierre Alain Gevenois, MD, PhD

1 From the Department of Radiology, Hôpital Erasme (A.M., P.A.G.), and Statistical Unit, Institut de Recherche Interdiscisplinaire en Biologie Humaine et Moléculaire (V.D.M.), Université Libre de Bruxelles, Brussels, Belgium; and Department of Histology, Université de Mons-Hainaut, Mons, Belgium (J.Z.). Received February 19, 2006; revision requested April 19; revision received May 21; accepted June 6; final version accepted July 25. Supported by the Erasme Funds for Medical Research. Address correspondence to A.M., Department of Radiology, CHU de Charleroi, Boulevard Paul Janson 92, 6000 Charleroi, Belgium (e-mail: Afarine{at}ladner-madani.com).


Figure 1A
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  		Figure 1a: Mean (a) RA960 and (b) RA970 values (with standard errors of the mean) measured at 20 effective mAs ({blacktriangleup}) and 120 effective mAs ({diamondsuit}) on 1.25-, 5.0-, and 10.0-mm-thick CT sections. Dose (P = .007 and P = .001, respectively), section thickness (P < .001 for both), and the interaction between dose and thickness (P = .036 and P = .005, respectively) were found to have significant effects on RA960 and RA970.

 

Figure 1B
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  		Figure 1b: Mean (a) RA960 and (b) RA970 values (with standard errors of the mean) measured at 20 effective mAs ({blacktriangleup}) and 120 effective mAs ({diamondsuit}) on 1.25-, 5.0-, and 10.0-mm-thick CT sections. Dose (P = .007 and P = .001, respectively), section thickness (P < .001 for both), and the interaction between dose and thickness (P = .036 and P = .005, respectively) were found to have significant effects on RA960 and RA970.

 

Figure 2
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  		Figure 2: Mean 1st percentile (P1) values (with standard errors of the mean) measured at 20 effective mAs ({blacktriangleup}) and 120 effective mAs ({diamondsuit}) on 1.25-, 5.0-, and 10.0-mm-thick CT sections. Section thickness (P < .001)—but not radiation dose (P = .910) or the interaction between dose and thickness (P = .215)—was found to have a significant effect on 1st percentile values.

 




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