Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print March 13, 2007, 10.1148/radiol.2432060450
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murakami, R.
Right arrow Articles by Yamashita, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murakami, R.
Right arrow Articles by Yamashita, Y.

Malignant Supratentorial Astrocytoma Treated with Postoperative Radiation Therapy: Prognostic Value of Pretreatment Quantitative Diffusion-weighted MR Imaging1

Ryuji Murakami, MD, Takeshi Sugahara, MD, Hideo Nakamura, MD, Toshinori Hirai, MD, Mika Kitajima, MD, Yoshiko Hayashida, MD, Yuji Baba, MD, Natsuo Oya, MD, Jun-ichi Kuratsu, MD, and Yasuyuki Yamashita, MD

1 From the Departments of Radiation Oncology (R.M., Y.B., N.O.), Diagnostic Radiology (T.H., M.K., Y.H., Y.B., Y.Y.), and Neurosurgery (H.N., J.i.K.), Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860-8556, Japan; and Department of Radiology, Kumamoto Red Cross Hospital, Kumamoto, Japan (T.S.). Received March 12, 2006; revision requested May 9; revision received May 20; accepted June 19; final version accepted September 1. Address correspondence to R.M. (e-mail: murakami{at}kaiju.medic.kumamoto-u.ac.jp).


Figure 1
View larger version (18K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 1: Flow chart of 79 malignant astrocytomas outlined according to RTOG-RPA classification (I–VI). NF = neurologic function, RT = radiation therapy.

 

Figure 2
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 2: Graph illustrates relationship between minimum ADC and survival time, as measured from the date of pretreatment MR imaging, in all patients, including 25 alive subjects. The patients who died within 1 year had tumors with a minimum ADC lower than 1.0 x 10–3 mm2/sec. {circ} = patients with AA who survived, bullet = patients with AA who died, {triangleup} = patients with GBM who survived, {blacktriangleup} = patients with GBM who died.

 

Figure 3
View larger version (11K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 3: Survival curves based on histopathologic diagnosis (AA vs GBM) and minimum ADC (≤1.0 x 10–3 mm2/sec vs >1.0 x 10–3 mm2/sec). {circ} = patients with AA and high minimum ADC (>1.0 x 10–3 mm2/sec), bullet = patients with AA and low minimum ADC (≤1.0 x 10–3 mm2/sec), {triangleup} = patients with GBM and high minimum ADC, {blacktriangleup} = patients with GBM and low minimum ADC.

 

Figure 4
View larger version (154K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 4: Transverse MR images obtained in 53-year-old man with GBM (RTOG-RPA class V). A, T2-weighted (3700/96), and, B, contrast-enhanced T1-weighted (627/17) images show an enhancing tumor with a cystic component and peritumor edema. C, On DW image (5378/139), the enhancing area has moderately high signal intensity. D, On ADC map, the enhancing area (arrow) has a minimum ADC of 1.2103 x 10–3 mm2/sec. This patient survived for 44 months after the initial MR examination.

 

Figure 5
View larger version (165K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 5: Transverse MR images obtained in 52-year-old man with GBM (RTOG-RPA class IV). A, T2-weighted (3600/96), and, B, contrast-enhanced T1-weighted (627/17) images show an enhancing tumor with a cystic component. C, On DW image (5378/139), the enhancing area has high signal intensity. D, On ADC map, the enhancing area (arrow) has a minimum ADC of 0.6635 x 10–3 mm2/sec. This patient died 16 months after the initial MR examination.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2007 by the Radiological Society of North America.