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Published online before print April 19, 2007, 10.1148/radiol.2433060267
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Results of Different Treatment Protocols1

Fiona M. Fennessy, MD, PhD, Clare M. Tempany, MD, Nathan J. McDannold, PhD, Minna J. So, MD, Gina Hesley, MD, Bobbie Gostout, MD, Hyun S. Kim, MD, George A. Holland, MD, Dennis A. Sarti, MD, Kullervo Hynynen, PhD, Ferenc A. Jolesz, MD, and Elizabeth A. Stewart, MD

1 From the Departments of Radiology (F.M.F., C.M.T., N.J.M., M.J.S., K.H., F.A.J.) and Obstetrics and Gynecology (E.A.S.), Harvard Medical School/Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Departments of Radiology (G.H.) and Obstetrics and Gynecology (B.G.), Mayo Clinic, Rochester, Minn; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.S.K.); Department of Radiology, Lahey Clinic, Burlington, Mass (G.A.H.); and Radnet Management, Los Angeles, Calif (D.A.S.). From the 2005 RSNA Annual Meeting. Received February 10, 2006; revision requested April 12; revision received July 17; accepted August 23; final version accepted October 4. Supported by InSightec, Haifa, Israel. Supported by National Institutes of Health grants 5R25CA089017-05 (F.A.J., M.J.S.), 5P01CA067165-08 (F.A.J.), and 1U41RR019703-01A2 (F.A.J.). F.M.F. supported by GE AUR Radiology Research Academic Fellowship. Address correspondence to F.M.F. (e-mail: ffennessy{at}partners.org).


Figure 1
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  		Figure 1: Bar graph demonstrates UFSQOL transformed SSSs at baseline, 3, 6, and 12 months after MR imaging–guided focused ultrasound surgery in patients in continued access study (CAS) and in those subdivided into treatment according to original and modified guidelines. Mean scores at 3, 6, and 12 months were compared with baseline score with Student t test. There was a significant decrease in mean score at all time points.

 

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  		Figure 2: Line graph demonstrates UFSQOL SSS decrease from baseline to 3, 6, and 12 months after treatment according to original and modified guidelines. At 3, 6, and 12 months, respectively, n was 91, 88, and 55 in original group and 58, 56, and 21 in modified group. Score decrease was compared between the two treatment profiles at each time point by using analysis of covariance. Mean score decrease was obtained by subtracting least-squares mean change from baseline at 3, 6, and 12 months. Change in least-squares mean was significantly greater in modified treatment group at 3 (P = .037) months after treatment.

 




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