DOI: 10.1148/radiol.2441060258
Probably Benign Breast Masses at US: Is Follow-up an Acceptable Alternative to Biopsy?1
Oswald Graf, MD,
Thomas H. Helbich, MD,
Gottfried Hopf, MD,
Claudia Graf, PhD, and
Edward A. Sickles, MD
1 From the Department of Radiology, ACC Steyr, Stadtplatz 30, A-4400 Steyr, Austria (O.G., G.H., C.G.); Department of Radiology, Medizinische Universität Wien, Vienna, Austria (T.H.H.); and Department of Radiology, University of California Medical Center, San Francisco, Calif (E.A.S.). Received February 10, 2006; revision requested April 11; revision received July 12; accepted August 22; final version accepted November 1.
Address correspondence to O.G. (e-mail: Oswald.Graf{at}utanet.at).

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Figure 1a: Images in 49-year-old woman with dense breast parenchyma. (a) In mediolateral oblique screening mammographic view, no lesion is visible. (b) In craniocaudal screening mammographic view, a circumscribed lesion (arrows) is visible, with more than 25% of circumference obscured by dense breast tissue. (c) On US scan, 9-mm well-circumscribed mass (arrows) of low echogenicity was found in upper inner quadrant and was classified as probably benign (BI-RADS category 3). Mass remained stable at follow-up for more than 3 years.
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Figure 1b: Images in 49-year-old woman with dense breast parenchyma. (a) In mediolateral oblique screening mammographic view, no lesion is visible. (b) In craniocaudal screening mammographic view, a circumscribed lesion (arrows) is visible, with more than 25% of circumference obscured by dense breast tissue. (c) On US scan, 9-mm well-circumscribed mass (arrows) of low echogenicity was found in upper inner quadrant and was classified as probably benign (BI-RADS category 3). Mass remained stable at follow-up for more than 3 years.
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Figure 1c: Images in 49-year-old woman with dense breast parenchyma. (a) In mediolateral oblique screening mammographic view, no lesion is visible. (b) In craniocaudal screening mammographic view, a circumscribed lesion (arrows) is visible, with more than 25% of circumference obscured by dense breast tissue. (c) On US scan, 9-mm well-circumscribed mass (arrows) of low echogenicity was found in upper inner quadrant and was classified as probably benign (BI-RADS category 3). Mass remained stable at follow-up for more than 3 years.
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Figure 2a: Images in 52-year-old woman with palpable lump in the right breast. (a) Craniocaudal and (b) spot-compression magnification screening mammographic views show an ill-defined mass with associated architectural distortion (arrows) in right breast. (c) US scan shows lesion corresponds to ill-defined mass of low echogenicity (arrows) in upper outer quadrant. The mass was classified as suspicious for carcinoma (BI-RADS category 5). (d) At US, an additional nonpalpable well-circumscribed mass (arrows) was seen in lower outer quadrant and was classified as probably benign. After surgical excision, a 15-mm invasive ductal carcinoma (stage pT1c) and a 10-mm fibroadenoma were diagnosed at histologic work-up, which confirmed US evaluation.
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Figure 2b: Images in 52-year-old woman with palpable lump in the right breast. (a) Craniocaudal and (b) spot-compression magnification screening mammographic views show an ill-defined mass with associated architectural distortion (arrows) in right breast. (c) US scan shows lesion corresponds to ill-defined mass of low echogenicity (arrows) in upper outer quadrant. The mass was classified as suspicious for carcinoma (BI-RADS category 5). (d) At US, an additional nonpalpable well-circumscribed mass (arrows) was seen in lower outer quadrant and was classified as probably benign. After surgical excision, a 15-mm invasive ductal carcinoma (stage pT1c) and a 10-mm fibroadenoma were diagnosed at histologic work-up, which confirmed US evaluation.
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Figure 2c: Images in 52-year-old woman with palpable lump in the right breast. (a) Craniocaudal and (b) spot-compression magnification screening mammographic views show an ill-defined mass with associated architectural distortion (arrows) in right breast. (c) US scan shows lesion corresponds to ill-defined mass of low echogenicity (arrows) in upper outer quadrant. The mass was classified as suspicious for carcinoma (BI-RADS category 5). (d) At US, an additional nonpalpable well-circumscribed mass (arrows) was seen in lower outer quadrant and was classified as probably benign. After surgical excision, a 15-mm invasive ductal carcinoma (stage pT1c) and a 10-mm fibroadenoma were diagnosed at histologic work-up, which confirmed US evaluation.
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Figure 2d: Images in 52-year-old woman with palpable lump in the right breast. (a) Craniocaudal and (b) spot-compression magnification screening mammographic views show an ill-defined mass with associated architectural distortion (arrows) in right breast. (c) US scan shows lesion corresponds to ill-defined mass of low echogenicity (arrows) in upper outer quadrant. The mass was classified as suspicious for carcinoma (BI-RADS category 5). (d) At US, an additional nonpalpable well-circumscribed mass (arrows) was seen in lower outer quadrant and was classified as probably benign. After surgical excision, a 15-mm invasive ductal carcinoma (stage pT1c) and a 10-mm fibroadenoma were diagnosed at histologic work-up, which confirmed US evaluation.
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Figure 3a: Images in 45-year-old woman. On (a) mediolateral oblique and (b) craniocaudal screening mammographic views, no abnormalities were identified. (c) Well circumscribed lesion of low echogenicity, 9 mm in largest diameter (arrows), was detected at US in retroareolar area. The mass was classified as probably benign (BI-RADS category 3). Lesion became palpable after 4 months; invasive ductal carcinoma was diagnosed after surgery.
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Figure 3b: Images in 45-year-old woman. On (a) mediolateral oblique and (b) craniocaudal screening mammographic views, no abnormalities were identified. (c) Well circumscribed lesion of low echogenicity, 9 mm in largest diameter (arrows), was detected at US in retroareolar area. The mass was classified as probably benign (BI-RADS category 3). Lesion became palpable after 4 months; invasive ductal carcinoma was diagnosed after surgery.
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Figure 3c: Images in 45-year-old woman. On (a) mediolateral oblique and (b) craniocaudal screening mammographic views, no abnormalities were identified. (c) Well circumscribed lesion of low echogenicity, 9 mm in largest diameter (arrows), was detected at US in retroareolar area. The mass was classified as probably benign (BI-RADS category 3). Lesion became palpable after 4 months; invasive ductal carcinoma was diagnosed after surgery.
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Copyright © 2007 by the Radiological Society of North America.