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DOI: 10.1148/radiol.2442060461
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Cancer Yield of Mammography, MR, and US in High-Risk Women: Prospective Multi-Institution Breast Cancer Screening Study1

Constance D. Lehman, MD, PhD, Claudine Isaacs, MD, Mitchell D. Schnall, MD, PhD, Etta D. Pisano, MD, Susan M. Ascher, MD, Paul T. Weatherall, MD, David A. Bluemke, MD, PhD, Deborah J. Bowen, PhD, P. Kelly Marcom, MD, Deborah K. Armstrong, MD, Susan M. Domchek, MD, Gail Tomlinson, MD, PhD, Steven J. Skates, PhD, and Constantine Gatsonis, PhD

1 From the Department of Radiology, University of Washington Medical Center, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3-200, Seattle, WA 98109-1023 (C.D.L.); Departments of Medicine and Oncology, Lombardi Comprehensive Cancer Center (C.I.), and Radiology (S.M.A.), Georgetown University, Washington, DC; Department of Radiology (M.D.S.) and Abramson Cancer Center (S.M.D.), University of Pennsylvania, Philadelphia, Pa; Department of Radiology, University of North Carolina, Chapel Hill, NC (E.D.P.); Department of Radiology (P.T.W.) and Center for Breast Care (G.T.), University of Texas–Southwestern Medical Center, Dallas, Tex; Russell H. Morgan Department of Radiology and Radiological Sciences and Department of Medicine (D.A.B.) and Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center (D.K.A.), Johns Hopkins University School of Medicine, Baltimore, Md; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash (D.J.B.); Department of Medical Oncology, Duke Comprehensive Cancer Center, Durham, NC (P.K.M.); Department of Biostatistics, Massachusetts General Hospital, Boston, Mass (S.J.S.); and Center for Statistical Sciences, Brown University, Providence, RI (C.G.). Received March 13, 2006; revision requested May 17; revision received August 30; accepted September 28; final version accepted December 11. Supported by the International Breast MRI Consortium (grants U01 CA74680 and 5 U01 CA74696) and the Cancer Genetics Network (grant U24 CA78146-01). Address correspondence to C.D.L. (e-mail: lehman{at}seattlecca.org).


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  		Figure 1: Flow chart shows enrollment, eligibility, and study findings.

 

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  		Figure 2: Negative screening mammogram and US of 46-year-old woman. Sagittal precontrast (A, T2-weighted fast spin-echo with fat suppression) and postcontrast (B, T1-weighted gradient-echo with fat suppression) images demonstrate 8 x 3 x 3 linear focus of enhancement in left breast (C) (arrow). Pathologic report proved infiltrating ductal carcinoma.

 




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