HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bellomi, M. Articles by Rocca, A. Search for Related Content PubMed PubMed Citation Articles by Bellomi, M. Articles by Rocca, A.

CT Perfusion for the Monitoring of Neoadjuvant Chemotherapy and Radiation Therapy in Rectal Carcinoma: Initial Experience¹

¹ From the School of Medicine, University of Milan, Milan, Italy (M.B., G.P.); and the Departments of Radiology (M.B., G.P.), Pathology and Laboratory Medicine (A.S.), and Medical Oncology (M.G.Z., A.R.), European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy. Received July 11, 2006; revision requested September 6; revision received October 9; accepted November 3; final version accepted January 10, 2007. Address correspondence to M.B. (e-mail: massimo.bellomi{at}ieo.it).

View larger version (119K): [in this window] [in a new window] [Download PPT slide]   Figure a: Rectal cancer, stage T3N1 (staged with endorectal US). (a) One section of the dynamic CT scan obtained before neoadjuvant chemoradiation therapy shows the tumor as thickening of the right lateral rectal wall. An 869-mm2 ROI was manually drawn along the margins of the rectal cancer for perfusion parameters calculation. (b) On the same section shown in a, a functional map of BF is designed by the software, showing the BF value calculated in each pixel of the image on a color scale. (c) CT scan obtained in the same patient after completion of neoadjuvant chemoradiation therapy shows a great reduction in the tumor; only a mild thickening of rectal wall can be seen and is outlined by the ROI, which is used to calculate perfusion CT values. (d) On the same section shown in c, the functional map of BF shows in a color scale the reduction in BF compared with b. (e) Pathologic surgical specimen shows thickening of the right lateral rectal wall due to inflammatory and cicatritial changes induced by therapy; no tumor cells were found at histologic examination, and the final pathologic stage was T0N0.

View larger version (176K): [in this window] [in a new window] [Download PPT slide]   Figure b: Rectal cancer, stage T3N1 (staged with endorectal US). (a) One section of the dynamic CT scan obtained before neoadjuvant chemoradiation therapy shows the tumor as thickening of the right lateral rectal wall. An 869-mm2 ROI was manually drawn along the margins of the rectal cancer for perfusion parameters calculation. (b) On the same section shown in a, a functional map of BF is designed by the software, showing the BF value calculated in each pixel of the image on a color scale. (c) CT scan obtained in the same patient after completion of neoadjuvant chemoradiation therapy shows a great reduction in the tumor; only a mild thickening of rectal wall can be seen and is outlined by the ROI, which is used to calculate perfusion CT values. (d) On the same section shown in c, the functional map of BF shows in a color scale the reduction in BF compared with b. (e) Pathologic surgical specimen shows thickening of the right lateral rectal wall due to inflammatory and cicatritial changes induced by therapy; no tumor cells were found at histologic examination, and the final pathologic stage was T0N0.

View larger version (101K): [in this window] [in a new window] [Download PPT slide]   Figure c: Rectal cancer, stage T3N1 (staged with endorectal US). (a) One section of the dynamic CT scan obtained before neoadjuvant chemoradiation therapy shows the tumor as thickening of the right lateral rectal wall. An 869-mm2 ROI was manually drawn along the margins of the rectal cancer for perfusion parameters calculation. (b) On the same section shown in a, a functional map of BF is designed by the software, showing the BF value calculated in each pixel of the image on a color scale. (c) CT scan obtained in the same patient after completion of neoadjuvant chemoradiation therapy shows a great reduction in the tumor; only a mild thickening of rectal wall can be seen and is outlined by the ROI, which is used to calculate perfusion CT values. (d) On the same section shown in c, the functional map of BF shows in a color scale the reduction in BF compared with b. (e) Pathologic surgical specimen shows thickening of the right lateral rectal wall due to inflammatory and cicatritial changes induced by therapy; no tumor cells were found at histologic examination, and the final pathologic stage was T0N0.

View larger version (151K): [in this window] [in a new window] [Download PPT slide]   Figure d: Rectal cancer, stage T3N1 (staged with endorectal US). (a) One section of the dynamic CT scan obtained before neoadjuvant chemoradiation therapy shows the tumor as thickening of the right lateral rectal wall. An 869-mm2 ROI was manually drawn along the margins of the rectal cancer for perfusion parameters calculation. (b) On the same section shown in a, a functional map of BF is designed by the software, showing the BF value calculated in each pixel of the image on a color scale. (c) CT scan obtained in the same patient after completion of neoadjuvant chemoradiation therapy shows a great reduction in the tumor; only a mild thickening of rectal wall can be seen and is outlined by the ROI, which is used to calculate perfusion CT values. (d) On the same section shown in c, the functional map of BF shows in a color scale the reduction in BF compared with b. (e) Pathologic surgical specimen shows thickening of the right lateral rectal wall due to inflammatory and cicatritial changes induced by therapy; no tumor cells were found at histologic examination, and the final pathologic stage was T0N0.

View larger version (188K): [in this window] [in a new window] [Download PPT slide]   Figure e: Rectal cancer, stage T3N1 (staged with endorectal US). (a) One section of the dynamic CT scan obtained before neoadjuvant chemoradiation therapy shows the tumor as thickening of the right lateral rectal wall. An 869-mm2 ROI was manually drawn along the margins of the rectal cancer for perfusion parameters calculation. (b) On the same section shown in a, a functional map of BF is designed by the software, showing the BF value calculated in each pixel of the image on a color scale. (c) CT scan obtained in the same patient after completion of neoadjuvant chemoradiation therapy shows a great reduction in the tumor; only a mild thickening of rectal wall can be seen and is outlined by the ROI, which is used to calculate perfusion CT values. (d) On the same section shown in c, the functional map of BF shows in a color scale the reduction in BF compared with b. (e) Pathologic surgical specimen shows thickening of the right lateral rectal wall due to inflammatory and cicatritial changes induced by therapy; no tumor cells were found at histologic examination, and the final pathologic stage was T0N0.