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DOI: 10.1148/radiol.2442060640
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Chronic Hypersensitivity Pneumonitis: CT Features—Comparison with Pathologic Evidence of Fibrosis and Survival1

Hakan Sahin, MD, Kevin K. Brown, MD, Douglas Curran-Everett, PhD, Valerie Hale, MD, Carlyne D. Cool, MD, Jason S. Vourlekis, MD, and David A. Lynch, MD

1 From the Department of Radiology (H.S., V.H., D.A.L.), Department of Medicine (H.S., K.K.B., C.D.C.), and Division of Biostatistics (D.C.), National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206; Division of Pulmonary Sciences and Critical Care Medicine (K.K.B.), Departments of Preventive Medicine and Biometrics (D.C.), Physiology and Biophysics (D.C.), and Pathology (C.D.C.), University of Colorado at Denver and Health Sciences Center, Denver, Colo; and Department of Medicine, Inova Fairfax Hospital (Medical Critical Care Service), Falls Church, Va (J.S.V.). From the 2005 RSNA Annual Meeting. Received April 11, 2006; revision requested June 21; final revision received October 16; accepted November 3; final version accepted January 16, 2007. Supported by National Institutes of Health grant HL67671. Address correspondence to H.S. (e-mail: sahinh{at}njc.org).


Figure 1A
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  		Figure 1a: Transverse thin-section CT scans in a patient with chronic HP with an HP pattern. (a) Scan obtained through midlungs shows ground-glass abnormality with mosaic attenuation. (b) Scan obtained through lower lungs shows ground-glass abnormality with mosaic attenuation.

 

Figure 1B
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  		Figure 1b: Transverse thin-section CT scans in a patient with chronic HP with an HP pattern. (a) Scan obtained through midlungs shows ground-glass abnormality with mosaic attenuation. (b) Scan obtained through lower lungs shows ground-glass abnormality with mosaic attenuation.

 

Figure 2A
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  		Figure 2a: Transverse thin-section CT scans in a patient with chronic HP and a UIP pattern. (a) Scan obtained through midlungs shows peripheral predominant reticular pattern and honeycombing. (b) Scan obtained through lower lungs shows basilar peripheral predominant reticular pattern, traction bronchiectasis, and honeycombing.

 

Figure 2B
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  		Figure 2b: Transverse thin-section CT scans in a patient with chronic HP and a UIP pattern. (a) Scan obtained through midlungs shows peripheral predominant reticular pattern and honeycombing. (b) Scan obtained through lower lungs shows basilar peripheral predominant reticular pattern, traction bronchiectasis, and honeycombing.

 

Figure 3
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  		Figure 3: Graph shows survival curves for patients with and patients without fibrotic HP at histologic examination. Evidence of fibrosis at histologic examination in chronic HP is associated with decreased survival.

 




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