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Figure 8b. (a,b) Color Doppler images of VX-2 tumors in a rabbit. (a) Color Doppler image obtained before contrast agent administration suggests a large solitary tumor (T, arrows) with poorly defined margins. (b) Delayed color Doppler image obtained 20 minutes after injection of 0.2 mL/kg SHU 563A shows the original tumor (T), as well as a second unsuspected area (t) that does not contain acoustic emission signals, which indicates the presence of an additional lesion—a small (4 x 3-mm) VX-2 tumor. (c) Pathologic specimen confirms the large tumor (T) and the small tumor (curved arrow) detected only after contrast agent administration. The photograph of the pathologic specimen was rotated 180° to correspond to b.