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Figure 4. Viral gene delivery. Planar scintigraphic image of the whole-body distribution of a genetically engineered herpes simplex virus utilized for gene delivery in a rat. The indium 111-labeled replication-conditioned virus encoding for ß-galactosidase was injected intravenously (150 µCi [5.6 MBq]). Image acquisition time was 5 minutes. Note the predominant viral distribution to liver (white and red areas), which should be useful for gene therapy in this organ (31).