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(Radiology. 2000;215:55-62.)
© RSNA, 2000


Medical Physics

Four Multidetector-Row Helical CT: Image Quality and Volume Coverage Speed1

Hui Hu, PhD, H. David He, PhD, W. Dennis Foley, MD and Stanley H. Fox, PhD

1 From GE Medical Systems, Milwaukee, Wis. From the 1998 RSNA scientific assembly. Received March 11, 1999; revision requested May 5; final revision received September 20; accepted October 4. Address reprint requests to H.H., 20720 W Watertown Rd, Suite 201, Waukesha, WI 53186 (e-mail: hui.hu@imagingtechinc.com).


    Abstract
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
PURPOSE: To evaluate the imaging performance characteristics of four multidetector-row helical computed tomography (CT) and assess improvement in volume coverage speed over that with single multidetector-row helical CT.

MATERIALS AND METHODS: The section-sensitivity profile and image noise of a four multidetector-row scanner were measured with phantom scans and compared with predictions from theoretic models. Nominal section thickness ranged from 1.25 to 10.00 mm, beam collimation from 1.25 to 5.00 mm, and table speed from 3.75 to 30.00 mm per rotation. Image artifacts with four and single multidetector-row helical CT were compared in both a phantom study and a subjective rating analysis of clinical images.

RESULTS: Compared with single multidetector-row helical CT, the volume coverage speed of four multidetector-row helical CT (range, 3.75–30.00 mm per rotation) is at least twice as fast as that with single multidetector-row helical CT (1.0–10.0 mm per rotation) with fully comparable image quality or, in many cases, three times as fast with diagnostically comparable image quality.

CONCLUSION: Compared with single multidetector-row helical CT, four multidetector-row helical CT provides a two- to threefold improvement in volume coverage speed with comparable diagnostic image quality.

Index terms: Computed tomography (CT), comparative studies • Computed tomography (CT), helical, **, 121152 • Computed tomography (CT), image processing • Computed tomography (CT), image quality


    Introduction
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
Successful application of computed tomography (CT) in medical diagnosis is, in many ways, dictated by the volume coverage speed of a scanner, which refers to its capability to rapidly scan a large volume of interest (eg, an entire lung or liver) with good image quality (ie, thin sections and low artifact rating). The time window for medical diagnostic applications is usually a fraction of a minute, which is imposed by (a) the short time window for optimal contrast enhancement, (b) a tolerable patient breath-hold duration for reduced image degradation induced by organ motion, and/or (c) the maximum scanning time without experiencing a lengthy tube cooling delay. Thus, one of the main themes in CT technologic development is improvement of the volume coverage speed of CT scanners.

Helical CT, introduced a decade ago (1,2), involves simultaneous transport of a patient at a constant speed through the gantry while helical CT data are continuously acquired over multiple gantry rotations. As a major improvement in the volume coverage speed, helical CT has become the method of choice for many routine and new clinical studies (39). It provides satisfactory image quality with a moderate table transport distance per rotation (eg, one to two times the section thickness to be imaged). However, further increase in the table transport speed (ie, the volume coverage speed) generally results in clinically unacceptable images (10). On the other hand, many time-critical applications, such as pulmonary embolism studies (8,9), multiphase dynamic organ studies (57), CT angiography (3), or neurologic and body trauma studies call for further improvement in the volume coverage speed of helical CT scanners.

The volume coverage speed may be substantially improved by using a combination of helical CT with so-called multidetector-row CT. " Multidetector-row CT scanner" refers to a special CT system equipped with a multiple-row detector array (Fig 1b) as opposed to the commonly used single-row detector array (Fig 1a). A two multidetector-row helical CT scanner (Twin; Elscint, Haifa, Israel) was introduced several years ago, and four multidetector-row helical CT scanners have recently been introduced by several CT manufacturers.



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Figure 1a. Diagrams depict perspective views of the (a) single and (b) four multidetector-row helical CT scanners. (Reprinted, with permission, from reference 11.) In a, 1D = one-dimensional; in b, 2D = two-dimensional.

 


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Figure 1b. Diagrams depict perspective views of the (a) single and (b) four multidetector-row helical CT scanners. (Reprinted, with permission, from reference 11.) In a, 1D = one-dimensional; in b, 2D = two-dimensional.

 
Owing to the distinct differences in the principles, constructions, and operations, four multidetector-row helical CT exhibits different imaging characteristics from those of single and two multidetector-row helical CT. The purpose of this study was to assess the volume coverage speed with four multidetector-row helical CT compared to that with single multidetector-row helical CT, which is widely used today. This assessment should be of clinical interest in terms of understanding the advantages and operations of four multidetector-row helical CT and assist the development of appropriate helical imaging protocols with such scanners.


    MATERIALS AND METHODS
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
Multidetector-Row Helical CT Data Acquisition
Four multidetector-row scanner.—The four multidetector-row helical CT scanner used in this study (LightSpeed QX/i; GE Medical Systems, Milwaukee, Wis) consists of a scalable multidetector-row detector and four multidetector-row data acquisition system. Along the axis of rotation (ie, the z axis), there are 16 rows of detector cells with a z spacing of 2.19 mm physically and 1.25 mm when projected onto the axis of rotation. As many as four adjacent detector rows may be grouped in the z direction by using electronic switches, which results in effective detector-row beam collimations of 1.25, 2.5, 3.75, or 5.0 mm when projected onto the z axis. The total x-ray beam is divided in the z direction into four subbeams with thickness determined by the detector-row beam collimation. The distances from the x-ray source to the detector and from the x-ray source to the axis of rotation are 94.9 and 54.1 cm, respectively.

Helical pitch.—The pitch at single multidetector-row helical CT is defined as the table transport distance per rotation divided by the x-ray beam collimation. For multidetector-row helical CT, this definition can be extended to the table transport distance per rotation divided by the detector-row beam collimation. With this extended definition, the pitch of multidetector-row helical CT is consistent with the convention of single multidetector-row helical CT in that the pitch relates the volume coverage speed to the thinnest sections that can be generated. We used the extended definition in this study.

Preferred helical pitches.—With multidetector-row helical CT, some pitches are preferred (11,12). At certain pitches, multiple detector rows work efficiently as one unit, and the data from different detector rows form a desirable z-sampling pattern. Selection of the pitches for multidetector-row helical CT is also affected by other conventional factors, such as the volume coverage speed (which disfavors very low pitch), section-sensitivity profile (SSP), and image artifact rating (which disfavors very high pitch). The four multidetector-row helical CT scanner used in this study supports two pitches: 3:1 and 6:1 (11). The combination of two pitches and four detector-row beam collimations results in eight scanning modes (Table 1).


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TABLE 1. Operation Matrix
 
Multidetector-Row Helical CT Image Reconstruction
The reconstruction algorithm for multidetector-row helical CT makes use of multiple-row data collection to minimize image degradation induced by rapid patient translation (11,12).

Multidetector-row helical interpolation algorithm.—From a multidetector-row helical data set, the multidetector-row helical interpolation algorithm synthesizes a complete set of projection data at each prescribed section location. The measurements closest to the section location, preferably from opposite sides, are used in the interpolation, regardless of which detector row produced them. The synthesized data set is then processed by using the standard reconstruction algorithm for conventional CT. Thus, reconstruction of a multidetector-row helical CT image normally requires the projection data from all detector rows.

z-Filtering reconstruction.—The four multidetector-row helical CT scanner makes use of the so-called z-filtering reconstruction algorithm, which allows multiple image sets with different section thicknesses to be reconstructed from a single helical CT data set by means of selection of appropriate z kernels. The concept of varying the frequency response of the z axis by means of z kernels (1113) is similar to that of varying the in-plane frequency response by means of the image reconstruction kernel, such as standard or lung kernels. The z-filtering reconstruction introduces flexibility in CT operation.

Operation Matrix
With the four multidetector-row scanner used in this study, the reconstructed images were grouped into six section thicknesses (hereafter, "nominal section thickness") of 1.25, 2.5, 3.75, 5.0, 7.5, and 10.0 mm. Table 1 is an operation matrix that shows the combinations of six nominal section thicknesses with eight scanning modes. Each cell in Table 1 represents a potential combination of scanning and reconstruction modes, which is referred to as a potential imaging (or operation) mode.

With the z-filtering reconstruction, multiple section thicknesses can be obtained with a given scanning mode (ie, with a fixed detector-row beam collimation and table speed). For example, three section thicknesses (ie, 2.5, 3.75, 5.0 mm) can be generated, by means of appropriate z-kernel selection, from a single data acquisition with pitch of 3:1 and table speed of 7.5 mm per rotation. In addition, several scanning modes can generate images with a prescribed section thickness. For example, six scanning modes can generate an image with nominal section thickness of 5.0 mm (Table 1).

Imaging Performance Study
Findings with four multidetector-row helical CT in the various helical CT modes were benchmarked to those with single multidetector-row helical CT with corresponding section thickness. Image quality was evaluated on the basis of SSP, image noise, and artifact ratings as determined with theoretic models, phantom experiments, and subjective rating analysis of clinical images. The phantom experiments and clinical studies were conducted with the same four multidetector-row scanner and a single multidetector-row helical CT scanner (HiSpeed CT/i; GE Medical Systems). The scanning parameters for phantom experiments were fixed to 120 kVp, 200 mA, and gantry rotational speed of 1 second with both scanners.

Experimental and theoretic studies of SSP and noise.—The SSP was measured by scanning a thin-disk phantom (14). The images of the phantom were reconstructed with 0.1-mm increment in the image z position. The SSP was obtained by plotting the mean CT number measured over the centered thin disk as a function of image z location. The SSP was characterized by its full width at half maximum (FWHM) and full width at 10th maximum.

Image noise was measured with a 20-cm-diameter water phantom and was derived by calculating the SD of CT numbers of the centered water phantom. To obtain the noise ratio, image noise with helical CT was normalized to that with conventional CT performed with the same nominal section thickness on the same scanner.

As for single multidetector-row helical CT (1419), theoretic models of SSP and image noise were developed for multidetector-row helical CT (11) (Appendix). On the basis of these models, the SSP and image noise ratio were derived for the various helical CT modes and were compared with the corresponding experimental measurements.

Experimental study of image artifacts.—Image artifacts were assessed by using a morphologic body phantom that contained human cadaveric shoulder and spinal bones. This phantom is particularly sensitive to helical CT artifacts as these bones cause rapid attenuation changes in the z direction. The artifact rating was derived subjectively by consensus of three observers, who were not blinded to the acquisition method. For example, if the artifacts with the four multidetector-row scanning mode were deemed comparable to those with single multidetector-row helical CT with 1:1-pitch and with comparable section thickness, the four multidetector-row artifacts were rated as "~1:1" (ie, equivalent to the single multidetector-row pitch of 1:1). When the section thickness (such as 2.5 mm) was not available on the single multidetector-row scanner or when the four multidetector-row artifact rating fell between those with single multidetector-row helical CT, the four multidetector-row artifact rating was derived by means of interpolation from the single multidetector-row ratings.

Subjective rating analysis of clinical images.—A preliminary evaluation of image quality and speed performance was conducted with the images of 13 patients (six men and seven women; age range, 23–75 years; mean age, 52 years). For each patient, two interval studies of the thorax, abdomen, and pelvis were available, one with single multidetector-row helical CT and the other with four multidetector-row helical CT. These 13 patients were from a larger group of patients who had undergone interval (1–2 months) oncologic survey studies for clinical staging of disease or posttreatment surveillance. The type of scanner used was determined on the basis of scanner availability at the time of their examination.

Single multidetector-row helical CT was performed with 5.0-mm beam collimation, table speed of 7.5 mm per rotation, and 5.0-mm reconstruction interval. Four multidetector-row helical CT was performed with 5.0-mm section thickness, table speed of 22.5 mm per rotation (ie, 3.75-mm detector-row beam collimation and 6:1 pitch), and 5.0-mm reconstruction interval. Imaging parameters with both the single and four multidetector-row helical CT scanners were determined on the basis of a preset clinical imaging protocol for each system. On images to be rated, comparable noise levels were ensured by using a milliampere-second setting for the second scan that was predicted to produce noise similar to that on the first scan.

Images at comparable anatomic levels from the two studies were displayed simultaneously on a two-screen workstation in a cine format. Oberservers were three board-certified radiologists experienced in reading body helical CT images. They were blinded to the acquisition method. The single and four multidetector-row images were displayed on either the left or right monitor, unknown to the observers. The observers reviewed the images simultaneously but independently.

Observers rated streak artifact across the midline soft-tissue anatomy on images obtained at the level of the upper thorax, upper abdomen, and midpelvis. Rib shadowing and streak artifacts between ribs were assessed on upper abdominal images. The artifact rating was assigned on a four-point scale: 0, none; 1, mild; 2, moderate; 3, severe. Diagnostic image quality was rated on a three-point scale: 1, diagnostic, less than standard image quality; 2, diagnostic and standard image quality; 3, optimal. The upper thorax was evaluated with mediastinal (level, 50 HU; width, 450 HU) and lung (level, -600 HU; width, 2,000 HU) window settings. The upper abdomen was evaluated with abdominal window settings (level, 50 HU; width, 350 HU). The midpelvis was evaluated with abdominal (level, 50 HU; width, 350 HU) and bone (level, 250 HU; width, 1,500 HU) window settings. Image quality evaluation for the upper thorax combined the assessment with mediastinal and lung window settings and for the midpelvis combined the assessment with abdominal and bone window settings.

Two viewing sessions separated by a 3-month interval included the same images and observers. Differences in artifact and image quality ratings were analyzed by means of a standard t test. A P value less than .05 was considered to indicate a statistically significant difference. Interobserver and intraobserver variability was assessed with the {kappa} statistic.


    RESULTS
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
Theoretic predictions and experimental measurements of SSP (in terms of FWHM and full width at 10th maximum) and the image noise ratio (the noise at helical CT compared to that with conventional CT with the same nominal section thickness and on the same scanner) were derived for the various scanning modes with four multidetector-row helical CT. As an example, the results with 5.0-mm nominal section thickness (Table 1) are tabulated in Table 2. The theoretic predictions and experimental measurements were in good agreement.


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TABLE 2. SSP and Noise with 5.0-mm Nominal Section Thickness
 
SSP and image noise ratio for each helical CT scanning mode with the four multidetector-row scanner are compiled in Table 3.


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TABLE 3. Operation Chart
 
To derive the artifact rating, images of the morphologic body phantom obtained with four multidetector-row helical CT were visually compared with those of comparable section thickness obtained with single multidetector-row helical CT. As an example, Figure 2 shows the corresponding images of the body phantom acquired with the various helical CT modes with 5.0-mm nominal section thickness. For example, the four multidetector-row helical CT scan obtained with 3:1 pitch and table speed of 11.25 mm per rotation (right column, second image from the top) appears to be comparable to the single multidetector-row helical CT scan obtained with 1:1 pitch (table speed of 5 mm per rotation) (left column, top image). Therefore, an artifact rating of ~1:1 was given to the four multidetector-row scanning mode (Table 3).



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Figure 2. Corresponding images obtained with 5.0-mm section thickness of a body phantom acquired with various helical CT modes. Left column, top to bottom: Single multidetector-row helical CT scans obtained with table speeds of 5.0, 7.5, 10.0, and 15.0 mm per rotation (rot) and pitches of 1.0, 1.5, 2.0, 3.0, respectively. Right column, top to bottom: Four multidetector-row helical CT scans acquired with table speed (millimeters per rotation) and detector-row beam collimation (millimeters), respectively, of (top three images with 3:1 pitch) 7.5 and 2.5, 11.25 and 3.75, 15.0 and 5.0, and (bottom three images with 6:1 pitch) 15.0 and 2.5, 22.5 and 3.75, and 30.0 and 5.0 (Table 1). Display window width, 350 HU and level, 30 HU. The image artifacts in the right column were assessed by using those in the left column as benchmarks.

 
The observer subjective ratings (mean for three observers, 13 patients, and two viewing sessions) are summarized in Table 4. Streak artifact increased at the level of the shoulders and midpelvis on the four multidetector-row studies (5.0-mm beam collimation, section thickness of 3.75-mm, table speed of 22.5 mm per rotation) as compared with the single multidetector-row studies (5.0-mm detector-row beam collimation, table speed of 7.5 mm per rotation). The difference was statistically significant (P < .05). Interobserver correlation was strong at the shoulder level ({kappa} = 0.61) and moderate at the midpelvis ({kappa} = 0.40). Intraobserver correlation was moderate at all three anatomic levels ({kappa} = 0.25), with complete agreement in 54% (62 of 114) of instances. Image quality for the four multidetector-row studies with increased artifacts at the shoulder and midpelvis was rated as diagnostically adequate and equivalent to that for the single multidetector-row studies. The increased streak artifact affected clinically unimportant soft-tissue anatomy (supraclavicular fossa at the shoulders, external pelvic musculature at the hips) or was limited to one section at the midpelvis.


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TABLE 4. Scores for Artifact and Image Quality Ratings with 5.0-mm Nominal Section Thickness
 
Figure 3 illustrates maximum intensity projection and multiplanar reformation images obtained in a renal donor with the four multidetector-row scanner (table speed of 7.5 mm per rotation, 1.25-mm detector-row beam collimation, pitch of 6:1). A volume coverage of 234 mm was achieved in 25 seconds with 1.6-mm (nominal, 1.25-mm) section thickness.



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Figure 3a. (a) Maximum intensity projection and (b) multiplanar reformation images from a renal donor study acquired with four multidetector-row helical CT (120 kVp, 370 mA, 0.8 second, table speed of 7.5 mm per rotation, 1.25-mm detector-row beam collimation, 1.25-mm reconstruction interval) with 234-mm coverage in 25 seconds and a 1.6-mm (nominal, 1.25-mm) section thickness. One hundred fifty milliliters of 60% contrast material (Omnipaque 300; Nycomed, Princeton, NJ) was injected at 5 mL/sec after the injection-to-scanning delay was determined with a preliminary small bolus (5 mL/sec for 4 seconds; then, transverse scanning of upper abdominal aorta after beginning of bolus and continued at 2-second intervals for 20 seconds). Bilateral accessory renal arteries to both renal hila are depicted clearly. In a, mesenteric arterial branches overlie the renal hila. In b, the separate aortic orifices (arrowheads) of all four renal arteries are demonstrated, and both left renal arteries are visible to their segmental divisions.

 


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Figure 3b. (a) Maximum intensity projection and (b) multiplanar reformation images from a renal donor study acquired with four multidetector-row helical CT (120 kVp, 370 mA, 0.8 second, table speed of 7.5 mm per rotation, 1.25-mm detector-row beam collimation, 1.25-mm reconstruction interval) with 234-mm coverage in 25 seconds and a 1.6-mm (nominal, 1.25-mm) section thickness. One hundred fifty milliliters of 60% contrast material (Omnipaque 300; Nycomed, Princeton, NJ) was injected at 5 mL/sec after the injection-to-scanning delay was determined with a preliminary small bolus (5 mL/sec for 4 seconds; then, transverse scanning of upper abdominal aorta after beginning of bolus and continued at 2-second intervals for 20 seconds). Bilateral accessory renal arteries to both renal hila are depicted clearly. In a, mesenteric arterial branches overlie the renal hila. In b, the separate aortic orifices (arrowheads) of all four renal arteries are demonstrated, and both left renal arteries are visible to their segmental divisions.

 
Figure 4 illustrates transverse images and coronal multiplanar reformation images from an abdominal study (table speed of 15.0 mm per rotation, 6:1 pitch, 2.5-mm detector-row beam collimation) with 225-mm coverage in 12 seconds. From the same helical CT data set, two sets of images were generated with section thicknesses of 5.0 and 3.2 mm (nominal, 2.5 mm).



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Figure 4. Transverse (top row) and coronal (bottom row) multiplanar reformation images of the upper abdomen reconstructed from a single multidetector-row helical CT acquisition (140 kVp, 260 mA, 0.8 second, table speed of 15.0 mm per rotation, 2.5-mm detector beam collimation, 1.25-mm reconstruction interval) with 225-mm coverage in 12 seconds and nominal section thicknesses of 5.0 mm (right column) and 2.5 mm (left column). One hundred fifty milliliters of 60% contrast material was injected at 3 mL/sec with an injection-to-scanning delay of 60 seconds. The thinner sections (left column) show sharper delineation of a dilated pancreatic duct (arrowhead in top row) and the adrenal glands, renal contour, and hemidiaphragms (arrowheads in bottom row) and are preferred for sharper z resolution. The thick sections (right column) may be preferred for reduced image noise and for fewer images to be archived and reviewed. (Image courtesy of Rendon C. Nelson, MD, Department of Radiology, Duke University Medical Center, Durham, NC.)

 

    DISCUSSION
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
The physical performance characteristics of multidetector-row helical CT differ from those with conventional CT or single multidetector-row helical CT primarily in terms of SSP, image noise, and artifacts. This comparison is similar to that between single multidetector-row helical and conventional CT (2,1417). The physical characteristics of four multidetector-row helical CT are summarized in Table 3.

Owing to the use of a multirow detector, multidetector-row helical CT can provide image quality that is comparable to or better (in terms of SSP and image artifacts) than that at single multidetector-row helical CT and with a faster table speed. Thus, the primary advantage of multidetector-row helical CT is a substantial improvement in volume coverage speed.

With 5.00-mm nominal section thickness (Tables 24, Fig 2), the SSP and image artifact ratings were comparable with (a) four multidetector-row helical CT at table speed of 11.25 mm per rotation and 3:1 pitch versus single multidetector-row helical CT at table speed of 5.0 mm per rotation, 5.0-mm section thickness, and 1:1 pitch, and (b) four multidetector-row helical CT at table speed of 15.0 mm per rotation and 3:1 or 6:1 pitch versus single multidetector-row helical CT at table speed of 7.5 mm per rotation, 5.0-mm section thickness, and 1.5:1.0 pitch. Volume coverage speed with four multidetector-row helical CT was at least twice that at single multidetector-row helical CT, and image quality (in terms of SSP and image artifacts) was comparable.

Findings in our clinical studies indicate that diagnostically comparable image quality can be achieved with approximately three times the volume coverage speed with four multidetector-row helical CT. On the basis of subjective ratings, image quality was comparable between four multidetector-row helical CT at table speed of 22.5 mm per rotation and 5.0-mm section thickness versus single multidetector-row helical CT at table speed of 7.5 mm per rotation and 5.0-mm section thickness. The four multidetector-row helical CT scans had more artifacts in some cases (Table 4) but were obtained three times faster and had a sharper SSP (FWHM, 5.0 vs 5.4 mm in Table 2). Image quality was also comparable between four multidetector-row helical CT at table speed of 15.0 mm per rotation and 3.2-mm (nominal, 2.5-mm) section thickness (Fig 4) versus single multidetector-row helical CT at table speed of 4.5 mm per rotation with 3.0-mm section thickness and 1.5:1.0 pitch, although the four multidetector-row helical CT scans were obtained about three times faster.

Findings in this study indicate that compared with single multidetector-row helical CT, the volume coverage speed of four multidetector-row helical CT can be at least twice as fast with fully comparable image quality or, in many cases, three times as fast with diagnostically comparable image quality.

Image quality (in terms of SSP and image artifacts) at helical CT deteriorates noticeably when the table transport speed is faster than 1.5–2.0 times the detector-row beam collimation per rotation (10). We found that the same is true for four multidetector-row helical CT even though the deterioration occurs at two- to threefold faster table speeds. At the fastest volume coverage speeds in our study with 1.25-, 2.5-, and 5.0-mm nominal section thicknesses, the FWHM was substantially larger than the corresponding nominal section thickness. For example, the FWHM with 5.0-mm nominal section thickness with table speed of 30.0 mm per rotation was 6.4 mm. This is because FWHM with 6:1 pitch (with linear interpolation) at four multidetector-row helical CT, which is similar to 2:1 pitch at single multidetector-row helical CT, cannot be thinner than 1.27 times the detector-row beam collimation (11). For the same reason, the mode of reconstructing 3.75-mm nominal section thickness at table speed of 22.5 mm per rotation is not provided. This is because the thinnest FWHM achievable from this scan is 4.76 mm (ie, 1.27 times its detector-row collimation of 3.75 mm), which should be categorized as the nominal section thickness of 5.0 mm rather than 3.75 mm, and which is redundant with the actual 5.0-mm imaging mode from the same scan.

The two- to threefold improvement in volume coverage speed provided with four multidetector-row helical CT could translate into (a) substantial improvement in volume coverage or z-axis resolution in routine CT studies, (b) better use of injected contrast materials, and (c) better separation of arterial and venous phases in multiphase data acquisitions. This improvement could allow routine scanning of a large region in the same contrast enhancement phase and with high spatial resolution in the z direction.

Results in this study can be applied independent of the implementation details of specific CT manufacturers. We used the same gantry rotational speed with both four and single multidetector-row helical CT. An increase in the gantry rotational speed would result in a proportional improvement in volume coverage speed. Similarly, to ensure the noise characteristics were generally independent of the imaging geometries and x-ray use efficiencies of specific scanners, we evaluated the noise ratios between helical and conventional CT with the same scanner with use of the same nominal section thickness. It was beyond the scope of this study to directly compare the image noise and milliampere-second settings between four and single multidetector-row helical CT, because these comparisons are affected by the imaging geometry and x-ray use efficiency of each particular scanner.

The noise ratio with four multidetector-row helical CT ranged from 0.82 to 0.92 for 3:1 pitch and 1.02 to 1.15 for 6:1 pitch (Table 3). With single multidetector-row helical CT, however, the noise ratio with the 180° linear interpolation algorithm was fixed to 1.15, regardless of pitch (14). Reduced noise ratios with four multide-tector-row helical CT were due to (a) the scan overlap with 3:1 pitch or (b) the z-filtering reconstruction, which allowed the z filtration to be fine-tuned to provide substantial noise reduction at the cost of a slight degradation in z resolution.

Four multidetector-row helical CT also provided the convenience of generating images from a single helical CT data acquisition that had multiple section thicknesses optimized for different applications (Table 3, Fig 4). Also, multiple scanning modes could be used to generate a prescribed section thickness (Tables 1, 3) with trade-offs in the volume coverage speed, image artifacts, SSP, noise, and section thickness at retrospective reconstruction.

As with single multidetector-row helical CT, four multidetector-row helical CT eliminates the scanning delay inherent in conventional CT and therefore has a faster volume coverage speed. In addition, four multidetector-row helical CT can provide images at any location within the scanning range with arbitrarily small section z spacing.


    APPENDIX
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 
The SSP of helical CT is predicted as follows:

where s is the table transport distance per rotation, d is the beam collimation, zs is the distance along the z axis to the reconstructed section, z is the table z position, b(z) is the SSP with conventional CT at the same beam collimation d, n is the detector-row index, which ranges from 1 to N, and wn is the helical interpolation function at the center detector channel of the nth detector row.

The noise ({sigma}) ratio of helical (H) to conventional (C) CT, is given as follows (11):

where ß is the gantry rotation angle.


    Acknowledgments
 
We thank the many radiologists and technologists at Froedtert Memorial Lutheran Hospital (Milwaukee, Wis) for their support of this study; Timothy McAuliffe, PhD, at the Department of Biostatistics, Medical College of Wisconsin (Milwaukee) for his assistance in statistical analysis; George Seidenschnur and the Image Quality team at GE Medical Systems for assisting this study; and Jim Markvicka at GE Medical Systems for preparing Figure 3.


    Footnotes
 
**. Multiple body systems. Back

Abbreviations: FWHM = full width at half maximum SSP = section-sensitivity profile

Author contributions: Guarantors of integrity of entire study, H.H., W.D.F.; study concepts, all authors; study design, H.H., W.D.F., H.D.H.; definition of intellectual content, all authors; literature research, H.H., W.D.F., H.D.H.; clinical studies, W.D.F., H.D.H.; experimental studies, H.H., H.D.H.; data acquisition and analysis, H.H., H.D.H., W.D.F.; statistical analysis, W.D.F.; manuscript preparation, H.H., W.D.F., H.D.H.; manuscript editing, all authors; manuscript review, H.H., W.D.F.


    References
 TOP
 Abstract
 Introduction
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 APPENDIX
 References
 

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E. G. McFarland, T. K. Pilgram, J. A. Brink, R. A. McDermott, C. V. Santillan, P. W. Brady, J. P. Heiken, D. M. Balfe, L. B. Weinstock, E. P. Thyssen, et al.
CT Colonography: Multiobserver Diagnostic Performance
Radiology, November 1, 2002; 225(2): 380 - 390.
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Am. J. Roentgenol.Home page
P. M. Boiselle, K. F. Reynolds, and A. Ernst
Multiplanar and Three-Dimensional Imaging of the Central Airways with Multidetector CT
Am. J. Roentgenol., August 1, 2002; 179(2): 301 - 308.
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Am. J. Roentgenol.Home page
S. Kawata, T. Murakami, T. Kim, M. Hori, M. P. Federle, S. Kumano, E. Sugihara, S. Makino, H. Nakamura, and M. Kudo
Multidetector CT: Diagnostic Impact of Slice Thickness on Detection of Hypervascular Hepatocellular Carcinoma
Am. J. Roentgenol., July 1, 2002; 179(1): 61 - 66.
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RadioGraphicsHome page
M. Mahesh
The AAPM/RSNA Physics Tutorial for Residents: Search for Isotropic Resolution in CT from Conventional through Multiple-Row Detector
RadioGraphics, July 1, 2002; 22(4): 949 - 962.
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ChestHome page
P. M. Boiselle and A. Ernst
Recent Advances in Central Airway Imaging*
Chest, May 1, 2002; 121(5): 1651 - 1660.
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P. R. Ros and H. Ji
Special Focus Session: Multisection (Multidetector) CT: Applications in the Abdomen
RadioGraphics, May 1, 2002; 22(3): 697 - 700.
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W. D. Foley
Special Focus Session: Multidetector CT: Abdominal Visceral Imaging
RadioGraphics, May 1, 2002; 22(3): 701 - 719.
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RadiologyHome page
F. R. Verdun, A. Denys, J.-F. Valley, P. Schnyder, and R. A. Meuli
Detection of Low-Contrast Objects: Experimental Comparison of Single- and Multi-Detector Row CT with a Phantom
Radiology, March 21, 2002; (2002) 2232010810.
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Br. J. Radiol.Home page
S J Golding and P C Shrimpton
Radiation dose in CT: are we meeting the challenge?
Br. J. Radiol., January 1, 2002; 75(889): 1 - 4.
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Arch SurgHome page
M. Sakon, H. Nagano, S. Nakamori, K. Dono, K. Umeshita, T. Murakami, H. Nakamura, and M. Monden
Intrahepatic Recurrences of Hepatocellular Carcinoma After Hepatectomy: Analysis Based on Tumor Hemodynamics
Arch Surg, January 1, 2002; 137(1): 94 - 99.
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ImagingHome page
U J Schoepf, C R Becker, R D Bruening, B M Ohnesorge, A Huber, L-G Haw, H Hildebrandt, and M F Reiser
Multislice CT angiography
Imaging, December 15, 2001; 13(5): 357 - 365.
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Am. J. Respir. Crit. Care Med.Home page
Y. NAKANO, H. O. COXSON, S. BOSAN, R. M. ROGERS, F. C. SCIURBA, R. J. KEENAN, K. R. WALLEY, P. D. PARE, and J. C. HOGG
Core to Rind Distribution of Severe Emphysema Predicts Outcome of Lung Volume Reduction Surgery
Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2195 - 2199.
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Am. J. Roentgenol.Home page
D. Y. Sze, M. K. Razavi, S. K. S. So, and R. B. Jeffrey Jr.
Impact of Multidetector CT Hepatic Arteriography on the Planning of Chemoembolization Treatment of Hepatocellular Carcinoma
Am. J. Roentgenol., December 1, 2001; 177(6): 1339 - 1345.
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RadiologyHome page
D. S. Katz and M. Hon
CT Angiography of the Lower Extremities and Aortoiliac System with a Multi-Detector Row Helical CT Scanner: Promise of New Opportunities Fulfilled
Radiology, October 1, 2001; 221(1): 7 - 10.
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E. K. Fishman
From the RSNA Refresher Courses: CT Angiography: Clinical Applications in the Abdomen
RadioGraphics, October 1, 2001; 21(90001): S3 - 16.
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H. Ji, J. D. McTavish, K. J. Mortele, W. Wiesner, and P. R. Ros
Hepatic Imaging with Multidetector CT
RadioGraphics, October 1, 2001; 21(90001): S71 - 80.
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RadiologyHome page
N. J. McNulty, I. R. Francis, J. F. Platt, R. H. Cohan, M. Korobkin, and A. Gebremariam
Multi-Detector Row Helical CT of the Pancreas: Effect of Contrast-enhanced Multiphasic Imaging on Enhancement of the Pancreas, Peripancreatic Vasculature, and Pancreatic Adenocarcinoma
Radiology, July 1, 2001; 220(1): 97 - 102.
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RadiologyHome page
T. R. Jones, R. T. Kaplan, B. Lane, S. W. Atlas, and G. D. Rubin
Single- versus Multi-Detector Row CT of the Brain: Quality Assessment
Radiology, June 1, 2001; 219(3): 750 - 755.
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RadiologyHome page
K. T. Bae and B. R. Whiting
CT Data Storage Reduction by Means of Compressing Projection Data Instead of Images: Feasibility Study
Radiology, June 1, 2001; 219(3): 850 - 855.
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Am. J. Roentgenol.Home page
K. A. Buckwalter, J. Rydberg, K. K. Kopecky, K. Crow, and E. L. Yang
Musculoskeletal Imaging with Multislice CT
Am. J. Roentgenol., April 1, 2001; 176(4): 979 - 986.
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RadiologyHome page
T. Murakami, T. Kim, M. Takamura, M. Hori, S. Takahashi, M. P. Federle, K. Tsuda, K. Osuga, S. Kawata, H. Nakamura, et al.
Hypervascular Hepatocellular Carcinoma: Detection with Double Arterial Phase Multi-Detector Row Helical CT
Radiology, March 1, 2001; 218(3): 763 - 767.
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RadiologyHome page
A. L. Weber
History of Head and Neck Radiology: Past, Present, and Future
Radiology, January 1, 2001; 218(1): 15 - 24.
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RadiologyHome page
A. L. Spielmann, R. C. Nelson, C. R. Lowry, G. A. Johnson, G. Sundaramoothy, D. H. Sheafor, and E. K. Paulson
Liver: Single Breath-hold Dynamic Subtraction CT with Multi-Detector Row Helical Technology—Feasibility Study
Radiology, January 1, 2002; 222(1): 278 - 283.
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