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Figure 11b. Three-dimensional model-based segmentation. Screenshot demonstrates elastic model-based segmentation of limbic structures, including amygdalae (green and yellow) and hippocampi (blue and red). (a) Segmentation is shown in three-dimensional surface rendering (bottom left) and two-dimensional overlay on T1-weighted MR images in three orthogonal planes (top left and right, bottom right). (b) Sagittal T1-weighted MR image demonstrates outline of hippocampus in green. (c) Hippocampus (yellow) and neighboring brain structures (blue, green, and red) are shown on three-dimensional volume rendering of the brain. (Images courtesy of Guido Gerig, PhD, University of North Carolina, Chapel Hill.)