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Figure 3b. (a) HiTT 106 system. Gross pathologic specimen shows morphologic changes that surround large vessel wall (arrow) and correspond mostly to white coagulative necrosis. Induced coagulation is distant from primary coagulation zone obtained after 20-minute RF application. Yellow area represents one of the four implanted guide marks. (b) Gross pathologic specimen after immunohistochemical assay shows DNA strand breaks (arrows) surrounding vessel. Assignment of DNA damage to white or red zone of coagulation was not achieved.