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Figure 4. Photomicrographs show histopathologic sections from tumors excised at day 7 after therapy. A, Slice from tumor treated with RF ablation alone (70°C for 5 minutes) shows typical appearance of heat-fixed tissue with rim of coagulative necrosis and peripheral areas of viable tumor. B, Slice from tumor treated with combined RF ablation and 20-Gy radiation therapy also shows an area of heat-fixed tissue. In this slice, however, marked hyperemia also is seen, with neovascular proliferation (black arrows) and edema (white arrows), and there is no evidence of viable tumor in the peripheral zone, which is composed of cellular debris. C, Slice from tumor treated with 20-Gy radiation therapy alone shows nothing but viable tumor cells. (Hematoxylin-eosin stain; original magnification, x10 [A and B] and x40 [C].)
