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Figure 1. Graphs show percent change in vascularity index (VI) and in levels of circulating angiogenic factors after thalidomide treatment for nonresponders versus responders. Four of five patients with response had a decrease in vascularity index, but 20 of 36 patients without response to thalidomide also had a decrease in vascularity index. Most patients had an increased level of PlGF after thalidomide therapy, without consistent changes in levels of VEGF and bFGF.
