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Figure 6b. Transverse T1-weighted gradient-echo MR images (2D gradient-echo sequence, 290/4.6, and 90° flip angle) and corresponding time course graphs for 45-year-old woman at high genetic risk for breast cancer who underwent screening with dynamic MR imaging. (a) In first subtracted postcontrast image for standard dynamic protocol, focal contrast-enhancing lesion (arrow) appeared to have round shape and smooth borders. (b) Graph demonstrates type 2 (plateau) signal intensity time course for standard dynamic protocol. Lesion was rated as BI-RADS category 3 (probable fibroadenoma). (c) In first subtracted postcontrast image for modified dynamic protocol, lesion (arrow) appeared ill defined and irregular. (d) Graph demonstrates type 3 (washout) signal intensity time for modified dynamic protocol. Lesion was rated as BI-RADS category 5. MR-guided excisional biopsy was performed and revealed 6-mm focal high-grade ductal carcinoma in situ.
