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Figure 5. Graphs illustrate results of contrast agent dose-response experiments. A, EB-stained (fluorescent) cell counts in fresh-frozen rat heart sections are plotted against contrast agent doses, with a nonlinear regression curve fitted to the data. B, Numbers of premature heartbeats recorded during myocardial contrast echocardiography of the rat hearts sampled in A. EB-stained cell counts and numbers of premature heartbeats increased rapidly with increasing contrast agent dose at low doses, but they leveled off at high doses.