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Figure 2: Images show transfer constant changes in 48-year-old postmenopausal woman with grade 2 infiltrating ductal-lobular carcinoma of the right breast responding to mitoxantrone and methotrexate chemotherapy. Columns show anatomic subtraction images (obtained by subtracting MR image acquired at 100 seconds after contrast agent administration from baseline image), corresponding transfer constant maps (color map displays range of 0–1 min–1), and histograms from pixel data. Rows show data before treatment and after one and two cycles of mitoxantrone and methotrexate chemotherapy, respectively. After one cycle of treatment (middle row), a decrease in the transfer constant median and range is seen (47% and 45%, respectively), compared with a 28% decrease in tumor size. After two treatments (bottom row), further decrease in transfer constant median and range is seen (80% and 75%, respectively) on the transfer constant histogram, compared with a 49% decrease in tumor size.
