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Figure 2c: Dynamic contrast-enhanced T1-weighted MR to assess permeability in a patient with high-grade glioma who has residual contrast enhancement after previous resection. Three-dimensional spoiled-gradient-echo sequence was performed every 6.45 seconds for 58 seconds after intravenous infusion of 0.1 mmol/kg gadopentetate dimeglumine. Five unenhanced images were first obtained at five different flip angles to derive T1 values of tissue needed for permeability analysis. (a) Transverse anatomic image of surgical site shows large enhancing region around surgical cavity. (b) Quantitative volume transfer constant (Ktrans) map between blood plasma and EES obtained at same location as in a shows marked increase in Ktrans (arrow) surrounding much of the surgical site. (c) Quantitative map of fractional plasma volume (vp) map obtained at same location as in a shows elevated vp (arrow) in only a small portion of the enhancing region (b and c generated with TOPPCAT; www.radweb.duke.edu/dbplab).
