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Figure 7f: Correspondence between increased ADC (increase > 55 x 10–5 mm2/sec) in pineal-region germ cell tumor and decreased tumor size after treatment. (a, c, e) Transverse T2-weighted MR images show color-coded regional spatial distribution of ADC changes on single sections, while (b, d, f) corresponding scatterplots (x-axis = ADC, y-axis = number of pixels) show ADC changes for three-dimensional tumor volume at (a, b) 1, (c, d) 3, and (e, f) 6 weeks after start of therapy. Increased ADC is shown as red pixels (on MR images) or points (on scatterplots); decreased ADC, as blue pixels or points; and unchanged ADC, as green pixels or points. At 1 week (a, b), 15% of pixels had ADC higher than baseline; at 3 weeks (c, d), 54% had ADC higher than baseline; and at 6 weeks (e, f), 63% had ADC higher than baseline. (Images courtesy of Brian Ross, PhD, University of Michigan, Ann Arbor.)
