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Figure 3: Average ROC curves for two-view observer study for three reading modes: independent (No CAD- Ind) (Az = 0.83), sequential without CAD (No CAD-Seq) (Az = 0.82), and sequential with CAD (With CAD-Seq) (Az = 0.87). The difference was significant for sequential with CAD mode versus independent mode (P = .03, Student paired t test; P < .05, Dorfman-Berbaum-Metz method) and for sequential with CAD mode versus sequential without CAD mode (P < .01, Student paired t test; P < .01, Dorfman-Berbaum-Metz method). Dashed line at true-positive fraction of 0.90 shows threshold above which Az(0.90) was calculated. For the two-view observer study, Az(0.90) was 0.35 for independent mode, 0.30 for sequential without CAD mode, and 0.49 for sequential with CAD mode. The difference was significant for sequential with CAD mode versus sequential without CAD mode (P < .01, Student paired t test).
