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Figure 6: Microautoradiographs show ß-galactosidase and 111In-oxine–labeled donor cells in the aorta and spleen of an atherosclerotic apolipoprotein E–deficient mouse. A, X-gal staining of a transverse frozen section of the aortic arch shows donor cells preferentially localized to the intima of atherosclerotic plaques (arrows). B, High-power magnification of healthy intima seen in A. C, High-power magnification of donor cells localizing to atherosclerotic plaques seen in A. D, Frozen slice of the spleen of a B6 apolipoprotein E–deficient mouse stained with ß-galactosidase after autoradiography to localize 111In-oxine. ß-Galactosidase–positive 111In-oxine–negative cells (top arrows) appear bluer than ß-galactosidase–positive 111In-oxine–positive cells (bottom arrow). The blue stain is an indicator of ß-galactosidase activity from donor BM.
