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Figure 1e: Histologic specimens obtained from different regions of the tibialis anterior at different time points in the ligation model illustrate changes in tissue over time: (a) central region before ligation; (b) central region immediately after ligation; (c) central region 3 days after ligation; (d) peripheral region 3 days after ligation; (e) central region 10 days after ligation, with three zones—degenerating zone (near tendon sheet [*]), inflammatory zone, and regenerating zone (small dotted lines); and (f) central region 21 days after ligation. Muscle recovery generally progressed from the outer regions to the central regions. Given examples (from different mice) are representative of all mice and all muscles, although the time course of recovery can vary between mice and between muscles. Muscles with a large cross-sectional area needed more time to recover than did smaller muscles. Arrows in a point to peripheral nuclei. In b–e, long black arrows point to rounder and/or swollen myocytes. In d and e, short black arrows point to inflammatory cells. In e and f, white arrows point to central nuclei. All slices were stained simultaneously with Gomori trichrome; therefore, differences in color did not originate from staining artifacts. Green color indicates collagen. (Original magnification, x10.)
